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Primary Intraosseous Malignancy Originating in an Odontogenic Cyst in a Young Child

2008; Elsevier BV; Volume: 66; Issue: 4 Linguagem: Inglês

10.1016/j.joms.2007.10.005

1531-5053

Makepeace Charles, Torin Barr, Iona Leong, Bo Ngan, Vito Forte, George K.B. Sándor,

Bone Tumor Diagnosis and Treatments

Primary intraosseous squamous cell carcinomas (PIOSCCs) are uncommon jaw malignancies derived from odontogenic epithelial remnants. The World Health Organization's classification of primary intraosseous carcinomas distinguishes among solid-type carcinomas, carcinomas originating from keratocystic odontogenic tumors (odontogenic keratocyst), and carcinomas derived from odontogenic cysts other than keratocystic odontogenic tumors. 1 Barnes L. Eveson J.W. Reichart P. World Health Organization Classification of Tumours: Pathology and Genetics of Head and Neck Tumours. IARC Press, Lyon, France2005: 290 Google Scholar Most PIOSCCs associated with cysts are well-differentiated squamous cell carcinomas arising from residual periapical cysts and dentigerous cysts; PIOSCCs originating from odontogenic keratocysts and orthokeratinized odontogenic cysts are less common. 1 Barnes L. Eveson J.W. Reichart P. World Health Organization Classification of Tumours: Pathology and Genetics of Head and Neck Tumours. IARC Press, Lyon, France2005: 290 Google Scholar , 2 Neville B.W. Damm D.D. Allen C.M. et al. Oral and Maxillofacial Pathology. in: (ed 2). Saunders, Philadelphia2002: 609 Google Scholar Carcinomas arising from all types of odontogenic cysts occur more frequently in men, and most patients are older adults, 2 Neville B.W. Damm D.D. Allen C.M. et al. Oral and Maxillofacial Pathology. in: (ed 2). Saunders, Philadelphia2002: 609 Google Scholar , 3 Norris L.H. Baghaei-Rad M. Maloney P.L. et al. Bilateral maxillary squamous odontogenic tumors and the malignant transformation of a mandibular radiolucent lesion. J Oral Maxillofac Surg. 1984; 42: 827 Abstract Full Text PDF PubMed Scopus (45) Google Scholar , 4 Gulbranson S.H. Wolfrey J.D. Raines J.M. et al. Squamous cell carcinoma arising in a dentigerous cyst in a 16-month-old girl. Otolaryngol Head Neck Surg. 2002; 127: 463 Crossref PubMed Scopus (42) Google Scholar , 5 Stoelinga P.F. Bronkhorst F.B. The incidence, multiple presentation and recurrence of aggressive cysts of the jaws. J Craniomaxillofac Surg. 1987; 16: 184 Abstract Full Text PDF Scopus (136) Google Scholar , 6 Fanibunda K. Soames J.V. Malignant and premalignant changes in odontogenic cysts. J Oral Maxillofac Surg. 1995; 53: 1469 Abstract Full Text PDF PubMed Scopus (25) Google Scholar , 7 Manganaro A.M. Cross S.E. Startzell J.M. Carcinoma arising in a dentigerous cyst with neck metastasis. Head Neck. 1997; 19: 436 Crossref PubMed Google Scholar , 8 Yasuoka T. Yonemoto K. Kato Y. et al. Squamous cell carcinoma arising in a dentigerous cyst. J Oral Maxillofac Surg. 2000; 58: 900 Abstract Full Text Full Text PDF PubMed Scopus (61) Google Scholar with a mean reported age of occurrence of 57 to 61 years. 2 Neville B.W. Damm D.D. Allen C.M. et al. Oral and Maxillofacial Pathology. in: (ed 2). Saunders, Philadelphia2002: 609 Google Scholar