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P4‐127: Cognitive Impairment and Differences Between Early and Late Onset Depression in a Sample from Outpatient Service of Geriatric Psychiatry

2010; Wiley; Volume: 6; Issue: 4S_Part_21 Linguagem: Inglês

10.1016/j.jalz.2010.08.186

1552-5279

Claudia M. Santana, Karol Casagrande Crepaldi, Arthur Guerra de Andrade, Tania C. T. Ferraz Alves,

Dementia and Cognitive Impairment Research

Memory complaints are also common in older adults with depression. Cognitive impairment in late onset depression (LOD) may be a result of the depressive disorder or an underlying dementing condition. Studies suggest that LOD is more often associated with cognitive impairment than early onset depression (EOD). It also seems that incident depression and gender interact in old age. The physiological impact of depression may be greater for men than for women despite the greater prevalence of depression among women. A retrospective study with patients from the outpatient service of geriatric psychiatry (public health system) that seek medical advice due to mental health complains. All of them were evaluated by a psychiatrist. Psychiatric disorders were categorized according to International Codification of Diseases (ICD 10) criteria. Data from depressive patients were analyzed into two different groups: an early onset depression group, consisting of patients first exhibiting depressive episodes before the age of 60 years; and a late onset depression group which included patients with depressive episodes starting after the age of 60 years. We assessed vascular risk factors and co-morbidities such as high blood pressure (HBP), high cholesterol level (HCL), smoking, cerebrovascular disease (CVD), diabetes, and heart diseases. Additionally, we evaluated marital status, education and cognitive status using the Mini-Mental State Examination (MMSE). A total data of 113 subjects were collected. From this sample, 25,66% (n= 29) full field criteria for LOD and 15,04% (n = 17) for EOD. No difference between MMSE was noted (average = 25); low level of education was noted in both groups (65,82% and 63,64% respectively, had up to 4 years of schooling). Gender difference was found: while 25,64% of women and 11,9% of men full field criteria for EOD; 23,08% and 26,19%, women and men, respectively, presented LOD. Differences between early and late onset depression have to be clarified in order to improve specific prevention, treatment and prognostic. Gender difference is a important feature to be analyzed. Beside of this sample not find difference between MMSE, a follow up will be conducted to evaluate the evolution of cognition in this groups.