Chemical Degradation of Peptides and Proteins in PLGA: A Review of Reactions and Mechanisms
2007; Elsevier BV; Volume: 97; Issue: 7 Linguagem: Inglês
10.1002/jps.21176
ISSN1520-6017
AutoresM.L. Houchin, Elizabeth M. Topp,
Tópico(s)Polymer Surface Interaction Studies
ResumoBiodegradable poly(lactide-co-glycolide) (PLGA) polymers have been studied extensively for the controlled release of peptide and protein drugs. In addition to polymer biodegradation, chemical degradation of the incorporated peptide/protein has also been reported in PLGA devices, and the role of the polymer in promoting these reactions has been debated. This review summarizes the peptide/protein chemical degradation reactions that have been reported in PLGA systems and their mechanisms. Reported methods for stabilizing peptides and proteins in PLGA devices are also discussed.
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