EFFECTS OF EPILEPTIC SEIZURES ON BRAIN RIBOSOMES: MECHANISM AND RELATIONSHIP TO CEREBRAL ENERGY METABOLISM
1977; Wiley; Volume: 29; Issue: 4 Linguagem: Inglês
10.1111/j.1471-4159.1977.tb07789.x
ISSN1471-4159
Autores Tópico(s)RNA and protein synthesis mechanisms
ResumoAbstract— Epileptic seizures were induced electrically in rats paralyzed and ventilated with oxygen. Dissociation of brain polysomes and increase in ribosomal dimers were observed after multiple (25 or more) seizures, but were not seen after shorter treatments (up to 10 seizures). Polysomal dissociation and dimer formation occurred in vivo and were accompanied by decreased amino acid incorporation into brain proteins in cell‐free systems in vitro. These events paralleled changes in brain energy reserves rather than changes in behavior.
Referência(s)