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Neuroblastoma in the newborn. A study of the Italian Neuroblastoma Registry

2009; Elsevier BV; Volume: 45; Issue: 18 Linguagem: Inglês

10.1016/j.ejca.2009.08.020

1879-0852

Anna Rita Gigliotti, Andrea Di Cataldo, Stefania Sorrentino, Stefano Parodi, A Rizzo, Piero Buffa, Claudio Granata, Angela Rita Sementa, Anna Maria Fagnani, Massimo Provenzi, Arcangelo Prete, Carmelita D’Ippolito, Anna Clerico, Aurora Castellano, Gian Paolo Tonini, Massimo Conte, Alberto Garaventa, Bruno De Bernardi,

Neonatal Health and Biochemistry

Aim Presenting features, treatment and outcome of 134 newborns with neuroblastoma diagnosed over a 27-year period are described. Methods Analyses were performed on the entire cohort and on patients distributed over three periods of diagnosis. Results Twenty-seven tumours (20.1%) were detected prenatally. Localised disease prevailed (65.7%) with an increase of stage 1 patients over time from 18.8% to 46.5%. Disseminated disease accounted for 34.3% of tumours with only one stage 4 and 45 stage 4S. Five-year overall survival (OS) of the entire cohort was 88.3%. Five/88 patients with localised disease died, including three who died of complications (OS, 95.3%). The only stage 4 patient survived. Eleven/45 stage 4S patients died, including 7/18 symptomatic and 4/27 asymptomatic (OS, 74.1%). Conclusion The outcome of neuroblastoma in newborns is excellent. In localised tumours, surgery-related deaths outnumbered deaths due to disease. Symptomatic stage 4S patients were at greater risk of dying.