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Hormonal Hypercholesterolemia in the Dog: Influence of Niacin, Niacinamide, Benzmalecene, and Cholestyramine Resin.

1963; SAGE Publishing; Volume: 112; Issue: 4 Linguagem: Inglês

10.3181/00379727-112-28229

1535-3702

Michela Zanetti, David M. Tennent,

Hormonal and reproductive studies

Pseudopregnant female dogs exhibited a characteristic hypercholesterolemia that was similar to that seen in true pregnancy in this laboratory. Daily subcutaneous injection of progesterone or prolactin raised blood cholesterol concentrations in male, anestrous female, and ovariectomized female dogs. The two hormones differed in their action. Niacin feeding counteracted the hypercholesterolemia of pseudopregnancy, and lowered plasma cholesterol levels in progesterone-injected or prolactin-injected ovariectomized female dogs. It had no effect on cholesterol concentrations of normal male or progesterone-injected male dogs. Niacinamide generally increased plasma cholesterol levels. Sodium benzmalecene lowered the blood cholesterol of a prolactin and a progesterone-injected female, and of a progesterone-injected male dog. Cholestyramine resin decreased the elevated cholesterol level of a progesterone-injected male dog.