Aging-Associated Cardiovascular Changes and Their Relationship to Heart Failure
2011; Elsevier BV; Volume: 8; Issue: 1 Linguagem: Inglês
10.1016/j.hfc.2011.08.011
ISSN2374-9334
AutoresJames B. Strait, Edward G. Lakatta,
Tópico(s)Cardiovascular and exercise physiology
ResumoAging represents a convergence of declining cardioprotective systems and increasing disease processes that is fertile ground for the development of heart failure. Fifty percent of all heart failure diagnoses and 90% of all heart failure deaths occur in individuals older than 70. This article discusses the microscopic and macroscopic changes in cardiovascular structure, function, protective systems, and disease associated with aging. In addition to outlining important clinical considerations and conditions in older persons, the link between normal aging and the elevated risk for development of stage B heart failure is explained and potential therapeutic pathways are highlighted.
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