Portal de Periódicos da CAPES

MECHANISM OF DIAZOXIDE HYPERGLYCEMIA IN ANIMALS

1968; Wiley; Volume: 150; Issue: 2 Linguagem: Inglês

10.1111/j.1749-6632.1968.tb19046.x

1749-6632

I.I.A. Tabachnick, A. Gulbenkian,

Eicosanoids and Hypertension Pharmacology

Annals of the New York Academy of SciencesVolume 150, Issue 2 p. 204-218 MECHANISM OF DIAZOXIDE HYPERGLYCEMIA IN ANIMALS I.I. A. Tabachnick, I.I. A. Tabachnick Department of Physiology and Biochemistry, Biological Research Division Schering Corporation, Bloomfield, N. J.Search for more papers by this authorA. Gulbenkian, A. Gulbenkian Department of Physiology and Biochemistry, Biological Research Division Schering Corporation, Bloomfield, N. J.Search for more papers by this author I.I. A. Tabachnick, I.I. A. Tabachnick Department of Physiology and Biochemistry, Biological Research Division Schering Corporation, Bloomfield, N. J.Search for more papers by this authorA. Gulbenkian, A. Gulbenkian Department of Physiology and Biochemistry, Biological Research Division Schering Corporation, Bloomfield, N. J.Search for more papers by this author First published: April 1968 https://doi.org/10.1111/j.1749-6632.1968.tb19046.xCitations: 32AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Bowles, W. E. & H. G. Langford 1964. A comparison of the antihypertensive effect of chlorthalidone and hydrochlorthiazide. Clin. Pharmacol. Therap. 5: 708. 2 Carliner, N. H., J. L. Schelling, R. P. Russell, R. Okun & M. Davis 1965. Thiazide-and phthalimidine-induced hyperglycemia in hypertensive patients. JAMA 191: 535– 540. 3 Chazan, J. A. & M. D. Boshell 1965. Etiological factors in thiazide-induced or aggravated diabetes mellitus. Diabetes 14: 132– 136. 4 El-Ebrashy, N., M. El-Danasoury & A. M. Higazi 1965. Hyperuricaemic and hyperglycaemic effects of thiazides in nonprediabetics. J. Egypt. Med. Assoc. 48: 467– 78. 5 Esbenshade, J. H., Jr & R. J. Smith 1965. Thiazides and pregnancy: A study of carbohydrate tolerance. Am. J. Obstet. Gynecol. 92: 270– 271. 6 Formanek, K. 1963. The effect of dihydrochlorothiazide on blood sugar regulation. Weiner Klinische Wochenschrift 75: 211– 213. 7 Goldner, M. G., H. Zarowitz & S. Akgun 1960. Hyperglycemia and glycosuria due to thiazide derivatives administered in diabetes mellitus. New Engl. J. Med. 262: 403– 05. 8 Greenberg, S. R., M. Dresner & R. Gorczyca 1963. The effect of thiazide diuretics on insulin antibodies. Am. J. Med. Sci. 246: 107– 109. 9 Hollis, W. C. 1961. Aggravation of diabetes mellitus during treatment with chlorothiazide. JAMA 176: 947– 949. 10 Kerstell, J. & A. Svanborg 1965. The influence of thiazides and chlorthalidone on the glucose tolerance in diabetes. Diabetologia 1: 146. 11 Mahr, G. & K. Rommel 1966. Clinical-experimental investigation on the effect of hydrochlorothiazide and furosemid on CHO metabolism. Klin. Wochschr. 44: 48. 12 Markkanen, T., E. Makila & U. Vaaja 1964. Hydrochlorothiazide and saliva. Drug Res. 14: 1222. 13 Nicole, C. J. & W. Pulver 1962. Hyperglycemic effect of saluretics in diabetes mellitus. Helv. Med. Acta 29: 556. 14 Rapoport, M. I. & H. F. Hurd 1964. Thiazide-induced glucose intolerance treated with potassium. Arch. Internal Med. 113: 405– 408. 15 Roediger, P. M., J. Alden, D. Beardwood & J. C. Hutchison 1964. Benzothiadiazines and diabetes mellitus. II, Comparison of hyperglycemic effects of bendroflume-thiazide and chlorothiazide in hypertensive patients with diabetes mellitus. Current Therap. Res. 6: 670. 16 Runyan, J. W. 1962. Influence of thiazide diuretics on carbohydrate metabolism in patients with mild diabetes. New Engl. J. Med. 267: 541– 543. 17 Shapiro, A. P., T. G. Benedek & J. L. Small 1961. Effect of thiazides on carbohydrate metabolism in patients with hypertension. New Engl. J. Med. 265: 1028– 33. 18 Sugar, S. 1961. Diabetic Acidosis during chlorothiazide therapy. JAMA 175: 164. 19 Rubin, A. D., F. E. Roth, R. M. Taylor & H. Rosenkilde 1962. Pharmacology of diazoxide, an antihypertensive, non-diuretic benzothiadiazine. J. Pharmacol. Exp. Therap. 136: 344. 20 Dollery, C. T., B. L. Pentecost & N. A. Samaan 1962. Drug-induced diabetes. Lancet 2: 735– 737. 21 Okun, R., R. P. Russell & W. R. Wilson 1963. Use of diazoxide with trichlormethiazide for hypertension. Arch. Internal Med. 112: 882– 888. 22 Wilson, W. R. & R. Okun 1962. The acute hemodynamic effects of diazoxide in man. Circulation 28: 89– 93. 23 Wilson, W. R., D. B. Stone, R. Okun & R. P. Russell 1964. Metabolic effects of diuretic and nondiuretic benzothiadiazines. Ann. Internal Med. 60: 317. 24 Wolff, F. W., W. W. Parmley, K. White & R. Okun 1963. Drug-induced diabetes. Diabetogenic activity of long-term administration of benzothiadiazines. JAMA 185: 568– 574. 25 Black, J., M. Eggert & D. Williams 1961. Hyperglycemia induced in dogs with a combination of diazoxide and trichlormethiazide. Unpublished data,Schering Corp. 26 Carminati, G. M. 1964. Azione diabetogena dei derivati benzotiodiazinici nel gatto. Experientia 11: 631. 27 Parmley, W. W., F. Wolff & L. Lasagna 1963. Thiazide-induced hyperglycemia. Bull. Johns Hopkins Hosp. 113: 33– 34. 28 Settle, H. P. Jr., R. J. Kiley, W. J. Munsie & J. A. Owen, Jr 1966. Chlorothiazidediazoxide hyperglycemia and nephrotoxicity in the intact rat. Clin. Res. 14: 78. 29 Wolff, F. W., R. G. Langdon, B. H. Ruebner, C. Hollander & R. D. Skoglund 1963. A new form of experimental diabetes. Diabetes 12: 335– 338. 30 Wilson, W. 1966. Treatment of hypertensive encephalopathy and crisis. Modern Treatment 3: 50– 61. 31 Okun, R., W. R. Wilson & M. D. Gelfond 1964. The hyperglycemic effect of hypotensive drugs. J. Chronic Diseases 17: 31– 39. 32 Wilson, W. R. & W. M. Kirkendall 1964. Effects of intravenous diazoxide in treatment of severe hypertension. Clin. Res. 12: 1964. 33 Gulbenkian, A., J. J. Petillo, L. J. Schobert, F. Seidman, A. Yannell & I.I. A. Tabachnick 1963. Hyperglycemic effect of diazoxide. Fed. Proc. 22: 543. 34 Gulbenkian, A., F. Seidman & I.I. A. Tabachnick 1964. Diazoxide hyperglycemia and free fatty acid mobilization. Fed. Proc. 23: 542. 35 Janes, R. G., R. J. Roelf & W. R. Wilson 1964. Effect of guanethidine and adrenal demedullation on hyperglycemic responses to diazoxide in rats. Proc. Soc. Exp. Biol. Med. 117: 572. 36 Kvam, D. C. & H. C. Stanton 1964. Studies on diazoxide hyperglycemia. Diabetes 13: 639– 644. 37 Senft, G. 1966. Beeinflussung hormonaler und enzymatischer regulationen des kohlenhydratstorfwechsels bei anwendung von benzothiadiazinen. Internist 8: 426– 435. 38 Tabachnick, I. I. A., A. Gulbenkian, W. Zeman & J. Black 1963. The effect of a benzothiadiazine on carbohydrate metabolism. Diabetes 12: 354. 39 Tabachnick, I. I. A., A. Gulbenkian & F. Seidman 1964. The effect of a benzothiadiazine, diazoxide, on carbohydrate metabolism. Diabetes 13: 408– 418. 40 Tabachnick, I.I. A., A. Gulbenkian & F. Seidman 1965. Further studies on the metabolic effects of diazoxide. J. Pharmacol. Exp. Therap. 150: 455– 467. 41 Kaess, H., G. Senft, W. Losert, R. Sitt & G. Schultz 1966. Mechanismus der gesteigerten glykogenolytischen wirkung des diazoxids im kaliummangel. Naunyn-Schmiedebergs Arch. Exp. Pathol. Pharmakol. 253: 395– 401. 42 Drash, A. & F. Wolff 1964. Drug therapy in leucine-sensitive hypoglycemia. Metabolism 13: 487– 491. 43 Pozza, G., A. Ghidoni & E. Sanesi 1965. Diazoxide treatment of leucine-sensitive hypoglycemia. Diabetologia 1: 149. 44 Drash, A., F. Wolff, H. Langs & R. Blizzard 1966. Diazoxide-induced diabetes mellitus in a hypopituitary dwarf. Diabetes 15: 319– 22. 45 Bleicher, S. J., F. Chowdhury & M. G. Goldner 1964. Thiazide therapy in hypoglycemia of metastatic insulinoma. Clin. Res. 12: 456. 46 Ernesti, M., M. L. Mitchell, M. S. Raben & Y. Gilboa 1965. Control of hypoglycemia with diazoxide and human growth hormone. Lancet 1: 628– 630. 47 Fajans, S. S., J. C. Floyd, R. F. Knopf, J. Rull, E. M. Guntsche & J. W. Conn 1966. Benzothiadiazine suppression of Insulin release from normal and abnormal islet tissue in man. J. Clin. Invest. 45: 481– 492. 48 Goldner, M. G. & S. J. Bleicher 1965. Thiazide therapy for organic hypoglycemia. Sixth Pan Am. Congress of Endocrinol., Mexico City , October 10–15. 49 Graber, A. L., D. Porte Jr. & R. H. Williams 1966. Clinical use of diazoxide and mechanism for its hyperglycemic effects. Diabetes 15: 143– 48. 50 Lundvall, O. & S. Johnsson 1965. Insuloma treated with diazoxide. Nord. Med. 73: 53– 56. 51 Marks, V., F. C. Rose & E. Samols 1965. Hyperinsulinism due to metastasizing insulinoma: Treatment with diazoxide. Proc. Roy. Soc. Med. 58: 577– 588. 52 Pozza, G., A. Ghidoni & E. Sanesi 1965. Trattamento con diazossido di un caso di ipoglicemia da iperplasia insulare. Metabolismo 1: 79– 89. 53 Marks, V. & E. Samols 1966. Hypoglycemia of non-endocrine origin (non-islet cell tumors). Proc. Roy. Soc. Med. 59: 338– 40. 54 Tucker, W. R., W. G. Ryan, B. F. Martin & T. B. Schwartz 1968. Studies in a patient with retroperitoneal sarcoma associated with severe hypoglycemia. This annal. 55 Spergel, G. & S. Bleicher 1966. Effect of diazoxide on plasma glucose insulin and lipids in von Gierke's disease. Diabetes 15: 406– 410. 56 Samols, E. & V. Marks 1966. The treatment of hypoglycemia with diazoxide. Proc. Roy. Soc. Med. 59: 811– 14. 57 Loubatieres, A., R. Alric, M. Mariani, H. De Malbosc & G. Ribes 1966. Le diazoxide exerce experimentalement une action ingibitrice sur la secretion basale d'insuline. C. R. Soc. Biol. 160: 168– 171. 58 Losert, W., G. Senft, R. Sitt, G. Schultz & H. Kaess 1966. Die beteiligung des insulins an der diazoxid-hyperglykamie. Naunyn-Schmiedebergs Arch. Exp. Pathol. Pharmakol. 253: 388– 394. 59 Seltzer, H. S. & E. W. Allen 1965. Inhibition of insulin secretion in diazoxidediabetes. Diabetes 14: 439. 60 Seltzer, H. & J. R. Crout 1966. Inhibition of insulin secretion by diazoxide and epinephrine. Clin. Res. 14: 101. 61 Frerichs, H. & W. Crentzfeld 1965. Insulin release from pancreas of the rat. Diabetologia 1: 80. 62 Howell, S. L. & K. W. Taylor 1965. Effects of diazoxide on insulin secretion in vitro. Lancet 1: 128– 129. 63 Wong, K. K., S. Symchowicz, M. S. Staub & I. I. A. Tabachnick 1967. The in vitro effect of catecholamines, diazoxide & theophylline in insulin release. Life Sciences 6: 2285. 64 Wolff, F. W. 1965. Drugs that cause diseases: The story of drug-induced diabetes. Clin. Med. 72: 309– 324. 65 Staquet, M. J., J. Nabwangu & F. Wolff 1965. The effect of thiazides on the blood sugar of alloxanized and suballoxanized rats. Metabolism 14: 1307– 1310. 66 Meng, K. & G. Kroneberg 1965. Untersuchungen au der ratte zur frage der diabetogenen wirkung von saluretica. Naunyn-Schmiedebergs Arch. Exp. Pathol. Pharmakol. 251: 433– 444. 67 Nabwangu, J., M. J. Staquet, J. K. Viktora, R. Yabo & F. W. Wolff 1965. Hormonal regulation of hyperglycemia due to diazoxide. Clin. Res. 13: 246. 68 Schultz, G., G. Senft, W. Losert & R. Sitt 1966. Biochemische grundlagen der diazoxid-hyperglykamie. Naunyn-Schmiedebergs Arch. Exp. Pathol. Pharmakol. 253: 372– 387. 69 Staquet, M., R. Yabo, J. Viktora & F. Wolff 1965. An adrenergic mechanism for hyperglycemia induced by diazoxide. Metabolism 14: 1000– 09. 70 Wolff, F. W., C. Cleveland, A. Drash, W. B. Parmley & R. Skoglund 1964. Etiological studies and novel application of diazoxide hyperglycemia. Clin. Res. 12: 282. 71 Loubatieres, A., M. M. Mariani, G. Ribes & H. De Malbosc 1966. Etude experimentale d'un sulfamide hyperglycemiant, le diazoxifle. C. R. Soc. Biol. 160: 165– 168. 72 Losert, W., G. Schaltz, G. Senft & R. Sitt 1966. The effect of diazoxide on the activity of glycogen phosphorylase and glycogen synthetase. Naunyn-Schmiedebergs Arch. Exp. Pathol. Pharmakol. 253: 69– 70. 73 Bleicher, S. J., F. Chowdhury, G. Weinstein & M. G. Goldner 1965. Effect of diazoxide on carbohydrate metabolism. Clin. Res. 13: 317. 74 Wolff, F. 1964. Diazoxide hyperglycemia and its continued relief by tolbutamide. Lancet 1: 309– 310. 75 Walfish, P. G. & S. S. Sanbar 1966. Insulin-1131 disappearance rates following diazoxide, epinephrine, and glucose administration. Clin. Res Res: 443. 76 Morgan, C. R. & A. Lazarow 1965. Immunoassay of pancreatic and plasma insulin following alloxan injection of rats. Diabetes 14: 669– 671. 77 Shore, P. A., D. Busfield & H. S. Alpers 1964. Binding and release of metaraminol: Mechanism of norepinephrine depletion by α-methyl-m-tyrosine and related agents. J. Pharmacol. Exp. Therap. 146: 194– 199. 78 Carlson, A. & B. Waldeck 1966. Release of 3H-metaraminol by different mechanisms. Acta Physiol Scand. 67: 471– 488. 79 Hertting, G., L. T. Potter & J. Axelrod 1962. Effect of decentralization and ganglionic blocking agents on the spontaneous release of H3-norepinephrine. J. Pharmacol. Exp. Therap. 136: 289– 292. 80 Plummer, A. J., J. H. Trapold, J. A. Schneider, R. A. Maxwell & A. E. Earl 1955. Ganglionic blockade by a new bisquarternary series, including chlorisondamine di-methochloride. J. Pharmacol. Exp. Therap. 115: 172– 184. 81 Burns, J. J., K. I. Colville, L. A. Lindsay & R. A. Salvador 1964. Blockade of some metabolic effects of catecholamines by N-isopropylmethoxamine (B.W. 61–43). J. Pharmacol. Exp. Therap. 144: 163– 171. 82 Salvador, R. A., K. I. Colville, S. A. April & J. J. Burns 1964. Inhibition of lipid mobilization by N-isopropylmethoxamine (B.W. 61–43). J. Pharmacol. Exp. Therap. 144: 172– 180. 83 Gordon, R. S., Jr & A. Cherkes 1958. Production of unesterified fatty acids from isolated rat adipose tissue incubated in vitro. Proc. Soc. Exp. Biol. Med. 97: 150. 84 Dole, V. P. 1956. A relationship between non-esterified fatty acids in plasma and the metabolism of glucose. J. Clin. Invest. 35: 150– 154. 85 Sanbar, S. S. 1966. Action of diazoxide on glucose metabolism and plasma lipids. Clin. Res. 14: 304. 86 Kaess, H., W. Losert, G. Schultz, G. Senft & R. Sitt 1966. On the mechanism of changes induced by diazoxide on the activity of the enzymes responsible for glycogen anabolism and catabolism. Naunyn-Schmiedebergs Arch. Exp. Pathol. Pharmakol. 253: 49– 51. 87 Sutherland, E. W. & G. A. Robison 1966. The role of cyclic 3′5′-AMP in response to catecholamines and other hormones. Pharmacol. Rev. 18: 145– 161. 88 Butcher, R. W. & E. W. Sutherland 1962. Adenosine 3′,5′-phosphate in biological materials. I. Purification and properties of cyclic 3′,5′-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3′,5′-phosphate in human urine. J. Biol. Chem. 237: 1244– 1250. 89 Hynie, S., G. Krishna & B. B. Brodie 1966. Theophylline as a tool in studies of the role of cyclic adenosine 3′,5′-monophosphate in hormone-induced lipolysis. J. Pharmacol. 153: 90– 96. 90 Porte, D., Jr 1966. Mechanisms for the regulation of serum insulin levels by catecholamines in man. J. Clin. Invest. 45: 1057– 58. 91 Porte, D., Jr & R. H. Williams 1966. Inhibition of insulin release by norepinephrine in man. Science 152: 1248– 1250. 92 Porte, D. Jr., A. L. Graber, T. Kuzuya & R. H. Williams 1966. The effect of epinephrine on immunoreactive insulin levels in man. J. Clin. Invest. 45: 228– 236. 93 Porte, D., Jr 1967. A receptor mechanism for the inhibition of insulin release by epinephrine in man. J. Clin. Invest. 46: 86– 94. 94 Turtle, J. R., G. K. Littleton & D. M. Kipnis Nature. (In press.). 95 Grodsky, G. ( Personal communication.). 96 Malaisse, W., F. Malaisse-Lagae & P. H. Wright 1966. Insulin secretion by the pancreas in vitro. Presented 48th meeting, Endocrine Society, June 20–25, Chicago , Ill . 97 Zarday, Z., J. Viktora & F. Wolff 1966. The effect of diazoxide on catecholamines. Metabolism 15: 257– 261. 98 Symchowicz, S. & C. A. Korduba Effect of diazoxide on uptake, release, and metabolism of catecholamines. This annal. 99 Rennick, B., M. Pryor & N. Voss 1964. Inhibition of the renal tubular transport of epinephrine by the benzothiadiazine compounds. J. Pharmacol. Exp. Therap. 143: 42– 46. 100 Barnett, C. A. & J. E. Whitney 1966. The effect of diazoxide and chlorothiazide on glucose uptake in vitro. Metabolism 15: 88– 93. 101 Ellis, S. & A. J. Eusebi 1965. Dissociation of epinephrine-induced hyperkalemia and hyperglycemia by adrenergic blocking drugs and theophylline; role of cyclic 3′,5′-AMP. Fed. Proc. 24: 151. Citing Literature Volume150, Issue2Diazozide and the Treament of HypoglycemiaApril 1968Pages 204-218 ReferencesRelatedInformation