Portal de Periódicos da CAPES

Potential cancer chemopreventive constituents of the leaves of Macaranga triloba

2003; Elsevier BV; Volume: 65; Issue: 3 Linguagem: Inglês

10.1016/j.phytochem.2003.10.026

1873-3700

Dae Sik Jang, Muriel Cuendet, Alison D. Pawlus, Leonardus B.S. Kardono, Kazuko Kawanishi, Norman R. Farnsworth, Harry H. S. Fong, John M. Pezzuto, A. Douglas Kinghorn,

Bioactive Compounds and Antitumor Agents

Activity-guided fractionation of the leaves of Macaranga triloba, using an in vitro bioassay based on the inhibition of cyclooxygenase-2, resulted in the isolation of a rotenoid, 4,5-dihydro-5′α-hydroxy-4′α-methoxy-6a,12a-dehydro-α-toxicarol (1), as well as 12 known compounds, (+)-clovan-2β,9α-diol, ferulic acid, 3,7,3′,4′-tetramethylquercetin, 3,7,3′-trimethylquercetin, 3,7-dimethylquercetin, abscisic acid, 1β,6α-dihydroxy-4(15)-eudesmene, 3β-hydroxy-24-ethylcholest-5-en-7-one, loliolide, scopoletin, taraxerol, and 3-epi-taraxerol. The structure of compound 1 was determined using spectroscopic methods. All isolates were evaluated for their potential to inhibit cyclooxygenases-1 and -2 by measuring PGE2 production, and to induce quinone reductase in cultured Hepa 1c1c7 mouse hepatoma cells.