First Report of an OXA-48-Producing Multidrug-Resistant Proteus mirabilis Strain from Gaza, Palestine
2015; American Society for Microbiology; Volume: 59; Issue: 7 Linguagem: Inglês
10.1128/aac.00565-15
ISSN1098-6596
AutoresLiang Chen, Nahed Al Laham, Kalyan D. Chavda, José R. Mediavilla, Michael R. Jacobs, Robert A. Bonomo, Barry N. Kreiswirth,
Tópico(s)Infections and bacterial resistance
ResumoABSTRACT We report the first multidrug-resistant Proteus mirabilis strain producing the carbapenemase OXA-48 (Pm-OXA-48) isolated at Al-Shifa hospital in Gaza, Palestine. Draft genome sequencing of Pm-OXA-48 identified 16 antimicrobial resistance genes, encoding resistance to β-lactams, aminoglycosides, fluoroquinolones, phenicols, streptothricin, tetracycline, and trimethoprim-sulfamethoxazole. Complete sequencing of the bla OXA-48 -harboring plasmid revealed that it is a 72 kb long IncL/M plasmid, harboring carbapenemase gene bla OXA-48 , extended spectrum β-lactamase gene bla CTX-M-14 , and aminoglycoside resistance genes strA , strB , and aph(3 ′ )-VIb .
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