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Neoplastic infiltration of laryngeal cartilages: Histocytochemical study

1992; Wiley; Volume: 102; Issue: 8 Linguagem: Inglês

10.1288/00005537-199208000-00008

1531-4995

Andrea Gallo, P. Mocetti, Marco de Vincentiis, Marilia Simonelli, S. Ciampini, P. Bianco, E Bonucci,

Cholangiocarcinoma and Gallbladder Cancer Studies

Abstract The relationship between cartilage and invading neoplastic cells was studied in 32 cases of laryngeal cancer by histological and cytochemical methods. Cartilage invasion was present in 12 cases, 10 of which were in proximity or in contact with areas of calcification and ossification. It was significantly correlated only to tobacco consumption ( P <.05) and, in regard to glottic tumors, to tumor diameter greater than 3 cm ( P <.01). Histologically, neoplastic invasion in cartilage was massive in 2 cases, occurred in areas of ossification in 4, between cartilage and bone in 4, and in epiglottic cartilage in 2. In 3 of the cases with bone invasion, there was also new bone formation. Hyaline cartilage and bone resorption was due to tartrate'resistant acid phosphatase (TRAP)‐positive giant cells; in epiglottic cartilage only mononuclear cells were present, some of which were TRAP'positive. These results show that neoplastic cells can promote not only resorption and formation of bone, but also resorption of cartilage, which is considered resistant to neoplastic invasion. The different types of resorbing cells in contact with hyaline cartilage and bone in laryngeal cancer, and elastic cartilage in epiglottic cancer, suggest that the structure of the tissue being resorbed can influence the type of resorbing cells.