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Biclonal expansion and heterogeneous lineage involvement in a case of chronic myeloproliferative disease with concurrent MPLW515L/JAK2V617F mutation

2009; Elsevier BV; Volume: 113; Issue: 6 Linguagem: Inglês

10.1182/blood-2008-01-136499

1528-0020

Kais Hussein, Oliver Bock, Katharina Theophile, Jérôme Schlué, Matthias Ballmaier, Nicolaus Kröger, Gudrun Göhring, Guntram Büsche, Hans Kreipe,

Chronic Myeloid Leukemia Treatments

To the editor: Chronic myeloproliferative diseases (CMPDs)/myeloproliferative neoplasms (MPNs) are caused by clonal mutations of tyrosine kinase or receptor genes such as BCR-ABL, JAK2V617F, and MPLW515L.[1][1],[2][2] Recently, we and others showed that these mutations may be combined in