Determination of 9-hydroxyellipticine by redox colorimetry
1992; Elsevier BV; Volume: 10; Issue: 6 Linguagem: Inglês
10.1016/0731-7085(92)80061-q
ISSN1873-264X
AutoresPascal Formisyn, F. PAUTET, Canh Tran Minh, Jacques Bourgois,
Tópico(s)Mass Spectrometry Techniques and Applications
ResumoThe chemical reactions involved in the decomposition of 9-hydroxyellipticine (9-OH-E), an anticancer agent, in polar solvents is explained. The reactions, which involve the formation of 9-oxo-ellipticine and the addition of a nucleophilic acid on the C10 site of the heterocyclic system, have been used to measure 9-OH-E quantitatively by colorimetry in solution and by reflection on paper surfaces. A method for the stabilization of 9-OH-E in polar solvents is proposed.
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