Genetics of IgA deficiency
1995; Wiley; Volume: 103; Issue: 7-8 Linguagem: Inglês
10.1111/j.1699-0463.1995.tb01442.x
ISSN1600-0463
AutoresLennart Truedsson, Berivan Baskin, Qiang Pan‐Hammarström, Hodjattallah Rabbani, Igor Vořechovský, Smith Rjh, Lennart Hammarström,
Tópico(s)Cystic Fibrosis Research Advances
ResumoIgA deficiency is the most common humoral defect in man and results in an increased susceptibility to respiratory tract and gastrointestinal infections. Both clinical and genetic data support a close relationship with common variable immunodeficiency, a disease which involves not only IgA and IgG production, but also, in half of the patients, IgM. It is likely that the two disorders represent an allelic condition with a variable expression of a common gene defect which is thought to be involved in the regulation of immunoglobulin class switching. It is possible that a single, autosomally inherited gene with a limited penetrance is responsible for the development of both these defects.
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