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Literature-curated protein interaction datasets

2008; Nature Portfolio; Volume: 6; Issue: 1 Linguagem: Inglês

10.1038/nmeth.1284

1548-7105

Michael E. Cusick, Haiyuan Yu, Alex Smolyar, K. Venkatesan, Anne‐Ruxandra Carvunis, Nicolas Simonis, Jean‐François Rual, Heather Borick, Pascal Braun, Matija Dreze, Jean Vandenhaute, Mary Galli, Junshi Yazaki, David E. Hill, Joseph R. Ecker, Frederick P. Roth, Marc Vidal,

Microbial Metabolic Engineering and Bioproduction

High-quality datasets are needed to understand how global and local properties of protein-protein interaction, or 'interactome', networks relate to biological mechanisms, and to guide research on individual proteins. In an evaluation of existing curation of protein interaction experiments reported in the literature, we found that curation can be error-prone and possibly of lower quality than commonly assumed.