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Long-Term Stability of Serum Sodium in Hemodialysis Patients

2010; Karger Publishers; Volume: 29; Issue: 3 Linguagem: Inglês

10.1159/000274460

1421-9735

Aldo J. Peixoto, Nayan Gowda, Chirag R. Parikh, Sergio F. F. Santos,

Bipolar Disorder and Treatment

<i>Background:</i> A direct relationship between dialysate-to-plasma sodium gradient, blood pressure and interdialytic weight gain exists in hemodialysis (HD) patients. The aim of this study was to delineate the long-term variability of serum sodium in HD patients. <i>Methods:</i> We performed a retrospective cohort analysis of serum sodium and other analytes routinely evaluated in 100 stable chronic HD patients observed for 12 months. <i>Results:</i> Individual levels across the cohort varied from 122 to 145 m<i>M</i>, but 12-month intraindividual coefficients of variation for sodium were low (pre-HD = 1.6%; post-HD = 1.8%) with overall variability similar to that related to laboratory assay variability especially when compared with other analytes (3.1–30.8%). Pre-HD serum sodium had a trend toward hyponatremia (mean 136 ± 0.8 m<i>M</i>). <i>Conclusion:</i> Serum sodium is stable over time in HD patients. Pre-HD serum sodium may be used as a parameter for individualizing dialysate sodium prescription.