A total synthesis of (±)-Mitomycin K. Oxidation of the mitosene C9-9a double bond by (hexamethylphosphoramido)oxodiperoxomolybdenum (VI) (MoO5 · HMPA)
1996; Elsevier BV; Volume: 37; Issue: 34 Linguagem: Inglês
10.1016/0040-4039(96)01312-3
ISSN1873-3581
AutoresZheng Wang, Leslie S. Jimenez,
Tópico(s)Microbial Natural Products and Biosynthesis
ResumoA synthesis of (±)-Mitomycin K has been achieved in thirteen steps from commerically available 2,5-dimethylanisole in a 1.36% overall yield. One of the key steps is the oxidation of the C9-9a double bond of 1 by (hexamethylphosphoramido)oxodiperoxomolybdenum (VI) to give 5a and b. This allows for the facile introduction of the C-9a methoxy group into the mitomycin skeleton.
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