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An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: Emerging ‘Novel Psychoactive Drugs’

2013; Elsevier BV; Volume: 23; Issue: 11 Linguagem: Inglês

10.1016/j.bmcl.2013.03.066

1464-3405

Warunya Arunotayanun, Jeffrey W. Dalley, Xi‐Ping Huang, Vincent Setola, Ric Treble, Leslie L. Iversen, Bryan L. Roth, Simon Gibbons,

Neurotransmitter Receptor Influence on Behavior

Novel Psychoactive Drugs (NPD) can be sold without restriction and are often synthetic analogues of controlled drugs. The tryptamines are an important class of NPD as they bind to the various serotonin (5-HT) receptor subtypes and cause psychosis and hallucinations that can lead to injury or death through misadventure. Here we report on the structure elucidation and receptor binding profiles of two widely marketed tryptamine-derived NPDs, namely alpha-methyl-tryptamine and 5-methoxy-N,N-diallyl-tryptamine.