Applications of N-BOC-diamines for the solution phase synthesis of ketopiperazine libraries utilizing a Ugi/De-BOC/Cyclization (UDC) strategy
1998; Elsevier BV; Volume: 39; Issue: 44 Linguagem: Inglês
10.1016/s0040-4039(98)01770-5
ISSN1873-3581
AutoresChristopher Hulme, John Peng, Bonnie Louridas, Paul R. Menard, Paul Krolikowski, N.Vasant Kumar,
Tópico(s)Quinazolinone synthesis and applications
ResumoThis communication reveals a novel application of the ‘so-called’ convertible isonitrile for the solution phase generation of ketopiperazine libraries. Use of mono N-BOC diamines in the Ugi multi-component reaction (MCR), followed by BOC removal and base treatment (a ‘3 step, 1-pot procedure’) affords ketopiperazines in good yield. The generality of this procedure was further explored revealing novel routes to dihydroquinoxalinones and 1,4-benzodiazepines respectively
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