Portal de Periódicos da CAPES

Bricanyl® Turbuhaler® and Ventolin® Rotahaler® in exercise‐induced asthma in children

1991; Wiley; Volume: 46; Issue: 3 Linguagem: Inglês

10.1111/j.1398-9995.1991.tb00571.x

1398-9995

José Manuel Lopes dos Santos, Henrique Costa, E. Ståhl, J. E. Wirén,

Respiratory and Cough-Related Research

Bricanyl® Turbuhaler® (0.5 mg terbutaline sulphate) and Ventolin® Rotahaler® (0.4 mg salbutamol) were compared in a randomized double‐blind placebo controlled study on exercise‐induced asthma in 19 children (14 boys) aged 7‐14 years. The study was carried out on 3 separate days. Asthmatic attacks were provoked by free range running. Peak expiratory flow (PEF) was measured before and after exercise. If PEF decreased by > 20 %, one inhalation from each of the inhalers was given under supervision of the investigator. Only one of the inhalers (none on the placebo day) delivered active drug. PEF was measured again 5 and 10 min after treatment. Already 5 min after treatment PEF had returned to baseline after active treatment. There was no statistically significant difference between the two active treatments. After placebo treatment, PEF did not return to baseline even at the 10 min post‐exercise measurement. Ten children needed extra medication after the last PEF measurement on the placebo day, whereas no child needed extra medication after any of the active treatments. No adverse events were reported in this study. In conclusion, Bricanyl Turbuhaler (0.5 mg) and Ventolin Rotahaler (0.4 mg) were equally efficacious in the treatment of exercise‐induced asthma in children.