Tandem cationic cyclisation–aziridinium ion formation–nucleophilic ring opening: new methodology for the stereocontrolled synthesis of substituted pyrrolidines
2001; Royal Society of Chemistry; Issue: 11 Linguagem: Inglês
10.1039/b102124i
ISSN1364-548X
AutoresM. A. Graham, Mark Thornton‐Pett, Christopher M. Rayner, Alan H. Wadsworth,
Tópico(s)Chemical Synthesis and Analysis
ResumoA novel tandem cationic cyclisation–aziridinium ion formation–nucleophilic ring opening procedure has been developed which provides powerful new methodology for the stereocontrolled synthesis of a wide variety of substituted pyrrolidines from acyclic precursors. The intermediate bicyclic aziridinium ions can be isolated and their structure has been confirmed by X-ray crystallography.
Referência(s)