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Hereditary Myeloperoxidase Deficiency: Study of 12 Cases

1982; Wiley; Volume: 29; Issue: 5 Linguagem: Inglês

10.1111/j.1600-0609.1982.tb00613.x

0036-553X

C Larrocha, Mercedes Fernández de Castro, Gumersindo Fontán, A Viloria, José Luis Fernández‐Chacón, Carmen Jiménez López-Guarch,

Medical and Biological Ozone Research

12 cases of hereditary myeloperoxidase (MPO) deficiency are reported. Histochemical stainings, lysosomal enzyme determinations, electron microscopic study of MPO and granulocytic function were performed. Family studies on 2 generations were carried out in 5 patients and histochemical stainings and biochemical lysosomal enzyme determinations were done. MPO deficiency was found to follow autosomal recessive inheritance and only rarely to have clinical effects.