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Localization of interleukin 6 mRNA in human tonsils by in situ hybridization

1989; Wiley; Volume: 19; Issue: 12 Linguagem: Inglês

10.1002/eji.1830191230

1521-4141

Alain Bosseloir, Elisabeth L. Hooghe‐Peters, Ernst Heinen, N. Cormann, C. Kinet-Denoël, L. Vanhaelst, Léon J. Simar,

Reproductive System and Pregnancy

Abstract We have investigated which areas produce interleukin 6 (IL 6) in human tonsils. This growth factor is required for the terminal differentiation of B lymphocytes into plasmocytes. Using 35 S‐labeled IL 6 cDNA we demonstrated IL 6 gene expression over various areas of the tonsils, with consistent exception of the follicles, by in situ hybridization. It is, therefore, proposed that B cells are stimulated during their migration out of the follicles.