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Pathologic cells as procoagulant substance of disseminated intravascular coagulation syndrome in acute promyelocytic leukemia

1976; Elsevier BV; Volume: 8; Issue: 3 Linguagem: Inglês

10.1016/0049-3848(76)90021-9

1879-2472

N Sakuragawa, Kaoru Takahashi, Mari Hoshiyama, Chozo Jimbo, Matsuzo Matsuoka, Yoshihisa Onishi,

Angiogenesis and VEGF in Cancer

Pathologic cells of acute promyelocytic leukemia were studied as a potential trigger substance for disseminated intravascular coagulation syndrome (DIC). The pathologic cells had both procoagulant and fibrinolytic activity. When this substance was separated by Sephadex G-200 column chromatography, procoagulant activity and fibrinolytic activity were observed in the same peak. Procoagulant activity was proven by prothrombin conversion activity, and fibrinolytic activity was proven by plasminogen free and plasminogen rich fibrin plate method. This procoagulant activity was inhibited by Trasylol and heparin, and fibrinolytic activity was inhibited by Trasylol and soybean trypsin inhibitor (STI). From the point of the effect of these inhibitors on the proteolytic action of the pathologic cells, Trasylol administration should be the best treatment for DIC of acute promyelocytic leukemia because Trasylol inhibited both hypercoagulation and hyperfibrinolysis. When the lysate of the pathologic cells of acute promyelocytic leukemia was infused into a rabbit, typical DIC was observed in laboratory studies, and many fibrin thrombi were observed in kidneys and lungs.