The role of prostaglandins in the control of the primary 19S immune response to sRBC
1977; Elsevier BV; Volume: 33; Issue: 1 Linguagem: Inglês
10.1016/0008-8749(77)90129-0
ISSN1090-2163
AutoresDavid R. Webb, Irene Nowowiejski,
Tópico(s)Macrophage Migration Inhibitory Factor
ResumoPrevious results demonstrated that sheep erythrocytes (sRBC) could stimulate a transient increase in splenic prostaglandin (PG) levels and that a block of this increase resulted in enhancement of the 19S primary immune response. The present study represents a more detailed analysis of the role of PG in the primary immune response to sRBC. The results demonstrate that an enhanced immune response to sRBC both in vivo and in vitro following a block of PG synthesis depends on both antigen dose and the basal level of the immune response in the absence of inhibitors of PG synthesis. Studies on the timing of the inhibition of PG synthesis show that PG apparently regulates both the early and late phases of the 19S response. By inhibiting PG synthesis, an enhancement of T helper function is observed in the presence of antigen. It is concluded that PG or products of the PG synthetase pathway are active during both the inductive and effector phases of the primary 19S response, and they appear to act on both T and R lymphocytes.
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