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Differences between muscular receptors and neurnal receptors for cholecystokinin-octapeptide in the guinea-pig gallbladder

1987; Elsevier BV; Volume: 136; Issue: 2 Linguagem: Inglês

10.1016/0014-2999(87)90721-7

1879-0712

Toku Takahashi, Takehira Yamamura, Masato Kusunoki, Masaru Kantoh, Yoshio Ishikawa, Joji Utsunomiya,

Cardiovascular, Neuropeptides, and Oxidative Stress Research

To investigate the differences between muscular and neural receptors for cholecystokinin-octapeptide (CCK-OP) in the guinea-pig gallbladder, we studied the effects of dibutyryl cyclic GMP (dbc GMP) on CCK-OP-evoked contraction and [3H]acetylcholine (ACh) release. 10−3 M dbc GMP significantly reduced CCK-OP (10−8 M)-evoked contractions without affecting the peptide-induced [3H]ACh release. It is suggested that there are two types of CCK-OP receptors in the guinea-pig gallbladder (dbc GMP-sensitive muscular receptors and dbc GMP-insensitive neural receptors).