Design and structure–activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): Tetramic, tetronic acids and dihydropyridin-2-ones
2008; Elsevier BV; Volume: 18; Issue: 6 Linguagem: Inglês
10.1016/j.bmcl.2008.02.009
ISSN1464-3405
AutoresStefan Peukert, Yingchuan Sun, Rui Zhang, Brian Hurley, Mike Sabio, Xiaoyu Shen, Christen Gray, JoAnn Dzink-Fox, Jianshi Tao, Regina E.J. Cebula, Sompong Wattanasin,
Tópico(s)Metal complexes synthesis and properties
ResumoBased on a pharmacophore hypothesis substituted tetramic and tetronic acid 3-carboxamides as well as dihydropyridin-2-one-3-carboxamides were investigated as inhibitors of undecaprenyl pyrophosphate synthase (UPPS) for use as novel antimicrobial agents. Synthesis and structure-activity relationship patterns for this class of compounds are discussed. Selectivity data and antibacterial activities for selected compounds are provided.
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