The effect of CCA (Lobenzarit disodium) on the suppressor T cell function and the production of autoantibodies in New Zealand Black and New Zealand White F1 mice
1983; Elsevier BV; Volume: 5; Issue: 4 Linguagem: Inglês
10.1016/0162-3109(83)90045-0
ISSN1879-047X
AutoresToshiaki Nakano, Yasuhiro Yamashita, Yoshiyuki Ohsugi, Yutaka Sugawara, Hata Shun-ichi, Yoshio Takagaki,
Tópico(s)Cytokine Signaling Pathways and Interactions
ResumoA newly synthesized agent, disodium 4-chloro-2,2'-iminodibenzoate (CCA; Lobenzarit disodium), which prevents the development of autoimmune disease in B/W mice, and inhibits adjuvant arthritis in rats, was investigated to clarify its mode of action in B/W mice. CCA protected against the age-related decline of the suppressor T cell activity which played an important role in the regulation of both humoral and cell-mediated immunity. CCA also decreased the production of naturally occurring thymocytotoxic autoantibody (NTA) preferentially cytotoxic against the thymocytes and suppressor T cells, and inhibited both the antibody production to double-stranded DNA and the appearance of ANA in B/W mice.
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