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Vaccine stabilization: Research, commercialization, and potential impact

2011; Elsevier BV; Volume: 29; Issue: 41 Linguagem: Inglês

10.1016/j.vaccine.2011.05.070

1873-2518

Debra Kristensen, Dexiang Chen, Ray Cummings,

Vaccine Coverage and Hesitancy

All vaccines are susceptible to damage by elevated temperatures and many are also damaged by freezing. The distribution, storage, and use of vaccines therefore present challenges that could be reduced by enhanced thermostability, with resulting improvements in vaccine effectiveness. Formulation and processing technologies exist that can improve the stability of vaccines at temperature extremes, however, customization is required for individual vaccines and results are variable. Considerations affecting decisions about stabilization approaches include development cost, manufacturing cost, and the ease of use of the final product. Public sector agencies can incentivize vaccine developers to prioritize stabilization efforts through advocacy and by implementing policies that increase demand for thermostable vaccines.