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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Effect of paternal age on human sperm chromosomes

2001; Elsevier BV; Volume: 76; Issue: 6 Linguagem: Inglês

10.1016/s0015-0282(01)02894-1

ISSN

1556-5653

Autores

Elza Maria Prestes Sartorelli, Luiz Fernando Mazzucatto, João Monteiro de Pina Neto,

Tópico(s)

Animal Genetics and Reproduction

Resumo

Objective: To investigate whether increased age alters the frequency and type of chromosomal anomalies in human spermatozoa.Design: Semen specimens were collected from donors via masturbation; cytogenetic studies were performed on sperm chromosomes after heterologous (human-hamster) in vitro fertilization.Setting: Cytogenetics Laboratory, Genetics Department, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil.Patients(s): Seven men ages 59–74 (older group) and five men ages 23–39 (control group).Main Outcome Measure(s): Frequency and types of chromosomal anomalies in older and control group donors.Result(s): The frequency of numerical and structural aberrations (acentric fragments and complex radial figures) was significantly greater in chromosomes of older donors when compared with those of the control group.Conclusion(s): The higher frequency of sperm chromosome aberrations in older men was mainly a result of increased nondisjunction, acentric fragments, and complex radial figures.

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