WT1 expression as a marker of minimal residual disease predicts outcome in acute myeloid leukemia when measured post-consolidation
2011; Elsevier BV; Volume: 36; Issue: 4 Linguagem: Inglês
10.1016/j.leukres.2011.09.005
ISSN1873-5835
AutoresJames X Gray, L. McMillen, Peter Mollee, Sanjoy K. Paul, Steven Lane, Robert Bird, Devinder Gill, Russell Saal, Paula Marlton,
Tópico(s)Renal and related cancers
ResumoWT1 levels may be a useful predictor of leukemia free survival (LFS) following treatment of acute myeloid leukemia (AML). We report a retrospective study in which levels of WT1 expression from patients with de novo AML were measured from bone marrow and peripheral blood at diagnosis, post-induction, post-consolidation and relapse. We demonstrate that higher levels of WT1 in peripheral blood at diagnosis are associated with poorer LFS independent of age and cytogenetic risk-group (n=85, p=0.028). When measured at post-consolidation, the presence of detectable WT1 is associated with poorer LFS in univariate analysis of both peripheral blood (p=0.024) and bone marrow (p=0.019). In a multivariate analysis including age and cytogenetic risk, the association remained significant for bone marrow (p=0.016) with a trend observed for peripheral blood (p=0.06). These findings have formed the basis for ongoing research.
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