Portal de Periódicos da CAPES

Multiple granular cell tumors associated with giant speckled lentiginous nevus and nevus flammeus in a child

1991; Elsevier BV; Volume: 24; Issue: 2 Linguagem: Inglês

10.1016/0190-9622(91)70052-4

1097-6787

Mary C. Guiglia, Julie Prendiville,

Tumors and Oncological Cases

We describe an 11-year-old girl in whom multiple cutaneous granular cell tumors were associated with a giant speckled lentiginous nevus and an extensive nevus flammeus. An association between granular cell tumors and pigmented skin lesions has been reported twice previously and supports a neural origin for these tumors. An abnormality of neural crest development is proposed to explain the coexistence of three uncommon and unusually extensive cutaneous disorders in this patient. This case may represent a further variant of phakoma-tosis pigmentovascularis. We describe an 11-year-old girl in whom multiple cutaneous granular cell tumors were associated with a giant speckled lentiginous nevus and an extensive nevus flammeus. An association between granular cell tumors and pigmented skin lesions has been reported twice previously and supports a neural origin for these tumors. An abnormality of neural crest development is proposed to explain the coexistence of three uncommon and unusually extensive cutaneous disorders in this patient. This case may represent a further variant of phakoma-tosis pigmentovascularis.