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MARVEL: a conserved domain involved in membrane apposition events

2002; Elsevier BV; Volume: 27; Issue: 12 Linguagem: Inglês

10.1016/s0968-0004(02)02229-6

1362-4326

Luis Sánchez‐Pulido, Fernando Martín‐Belmonte, Alfonso Valencia, Miguel A. Alonso,

Cell Adhesion Molecules Research

Abstract MARVEL is a novel domain with a four transmembrane-helix architecture that has been identified in proteins of the myelin and lymphocyte (MAL), physins, gyrins and occludin families. Association with specialized membrane microdomains has been reported for some of these MARVEL domain-containing proteins. Their function could be related to cholesterol-rich membrane apposition events in a variety of cellular processes, such as biogenesis of vesicular transport carriers or tight junction regulation. The MARVEL domain appears to be related to complex human diseases, such as schizophrenia and inflammation.