Portal de Periódicos da CAPES

A case—control study of risk factors for sarcomas of the uterus

1989; Wiley; Volume: 64; Issue: 12 Linguagem: Inglês

10.1002/1097-0142(19891215)64

1097-0142

Stephen M. Schwartz, David B. Thomas,

Endometrial and Cervical Cancer Treatments

CancerVolume 64, Issue 12 p. 2487-2492 ArticleFree Access A case—control study of risk factors for sarcomas of the uterus Stephen M. Schwartz MPH, Stephen M. Schwartz MPH Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WashingtonSearch for more papers by this authorDavid B. Thomas MD, DrPH, Corresponding Author David B. Thomas MD, DrPH Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WashingtonFred Hutchinson Cancer Research Center, 1124 Columbia Street (MP-474), Seattle, WA 98104===Search for more papers by this authorThe world health organization collaborative study of neoplasia and steroid contraceptives, The world health organization collaborative study of neoplasia and steroid contraceptives Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington The data collection centers, and the principal investigator (PI), co-investigator (CI), and pathologist (P) at each center, in alphabetical order by country, are as follows: University of Chile, Faculty of Medicine, Hospital Jose Joaquin Aguirre, Department of Obstetrics and Gynecology, and the Ministry of Health, Hospital Salvador, Department of Obstetrics and Gynecology, Santiago, Chile: Ramiro Molina (PI), Luis Martinez (CI), Oriana Salas (CI), and Alfredo Dabancens (P); Shanghai Institute of Planned Parenthood Research, Shanghai, China: Chen Zhihong (PI), Tao Yun (CI), and Hu Yong Wei (P); Hospital Universitario, WHO Collaborating Center for Research in Human Reproduction, Cali, Colombia: Alvaro Cuadros (PI) and Nubia Aristizabal (P); Chaim Sheba Medical Center, Department of Clinical Epidemiology, Tel Hashomer, Israel: Baruch Modan (PI), Elaine Ron (CI), and Esther Alfandary (CI); Hospital General de Mexico, Mexico City, Mexico: Hector Rodriguez Cuevas (PI), Socorro Benavides Salazar (CI), Antonio Palet (P), and Patricia Ontiveros (P); University of Ibadan, Ibadan, Nigeria: Patrick A. Ibeziako (PI), A.A. Abioye (P), T.A. Junaid (P), and Patrick U. Aghadiuno (P); University of the Philipines, College of Medicine, Manilla, Philipines: Ruben A. Apelo (PI), Julietta R. de la Cruz (CI), Jose Baens (CI), and Benjamin D. Canlas, Jr (P); Chulalongkorn University, Faculty of Medicine, Department of Obstetrics and Gynecology, WHO Collaborating Center for Research in Human Reproduction, Bangkok, Thailand: Banpot Boosiri (PI), Supawat Chutivongse (PI), Pramuaen Virutamasen (CI), Chansuda Wongsrichanalai (CI), and Sermsri Sindvananda (P); Mahidol University, Faculty of Medicine, Siriraj Hospital, Department of Obstetrics and Gynecology, Family Planning Research Unit, Bankok, Thailand: Suporn Koetsawang (PI), Daungdao Rachawat (CI), and Amorn Koetsawang (P).Search for more papers by this author Stephen M. Schwartz MPH, Stephen M. Schwartz MPH Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WashingtonSearch for more papers by this authorDavid B. Thomas MD, DrPH, Corresponding Author David B. Thomas MD, DrPH Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WashingtonFred Hutchinson Cancer Research Center, 1124 Columbia Street (MP-474), Seattle, WA 98104===Search for more papers by this authorThe world health organization collaborative study of neoplasia and steroid contraceptives, The world health organization collaborative study of neoplasia and steroid contraceptives Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington The data collection centers, and the principal investigator (PI), co-investigator (CI), and pathologist (P) at each center, in alphabetical order by country, are as follows: University of Chile, Faculty of Medicine, Hospital Jose Joaquin Aguirre, Department of Obstetrics and Gynecology, and the Ministry of Health, Hospital Salvador, Department of Obstetrics and Gynecology, Santiago, Chile: Ramiro Molina (PI), Luis Martinez (CI), Oriana Salas (CI), and Alfredo Dabancens (P); Shanghai Institute of Planned Parenthood Research, Shanghai, China: Chen Zhihong (PI), Tao Yun (CI), and Hu Yong Wei (P); Hospital Universitario, WHO Collaborating Center for Research in Human Reproduction, Cali, Colombia: Alvaro Cuadros (PI) and Nubia Aristizabal (P); Chaim Sheba Medical Center, Department of Clinical Epidemiology, Tel Hashomer, Israel: Baruch Modan (PI), Elaine Ron (CI), and Esther Alfandary (CI); Hospital General de Mexico, Mexico City, Mexico: Hector Rodriguez Cuevas (PI), Socorro Benavides Salazar (CI), Antonio Palet (P), and Patricia Ontiveros (P); University of Ibadan, Ibadan, Nigeria: Patrick A. Ibeziako (PI), A.A. Abioye (P), T.A. Junaid (P), and Patrick U. Aghadiuno (P); University of the Philipines, College of Medicine, Manilla, Philipines: Ruben A. Apelo (PI), Julietta R. de la Cruz (CI), Jose Baens (CI), and Benjamin D. Canlas, Jr (P); Chulalongkorn University, Faculty of Medicine, Department of Obstetrics and Gynecology, WHO Collaborating Center for Research in Human Reproduction, Bangkok, Thailand: Banpot Boosiri (PI), Supawat Chutivongse (PI), Pramuaen Virutamasen (CI), Chansuda Wongsrichanalai (CI), and Sermsri Sindvananda (P); Mahidol University, Faculty of Medicine, Siriraj Hospital, Department of Obstetrics and Gynecology, Family Planning Research Unit, Bankok, Thailand: Suporn Koetsawang (PI), Daungdao Rachawat (CI), and Amorn Koetsawang (P).Search for more papers by this author First published: 15 December 1989 https://doi.org/10.1002/1097-0142(19891215)64:12 3.0.CO;2-KCitations: 28 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Using data collected as part of the hospital-based World Health Organization (WHO) Collaborative Study of Neoplasia and Steroid Contraceptives, the authors examined potential risk factors for sarcoma of the uterus. Twenty-nine patients with uterine sarcoma who were between 15 and 56 years of age and diagnosed at one of nine centers were matched on age and center to 198 controls selected from hospital admissions to other than obstetric and gynecologic wards. All women were interviewed regarding their medical and reproductive history, methods of birth control, and history of sexual relationships and of sexually transmitted infections. The risk of uterine sarcoma was lower in parous women compared to nulliparous women (odds ratio [OR] = 0.6; 95% confidence interval [CI] = 0.1,3.3), and the risk decreased with increasing number of live births. A greater proportion of cases than controls reported giving birth to their first child at the age of 25 or later, even after adjustment for parity (OR = 3.5; 95% CI = 1.2,10.9). Cases were also more likely than controls to report a history of a spontaneous abortion (OR = 2.5; 95% CI = 0.8,7.4) or an induced abortion (OR = 1.6; 95% CI = 0.4,6.3). Late menarche and early menopause were both positively associated with the risk of uterine sarcoma. No association was observed with a history of infertility, use of oral contraceptives, or measures of sexual activity. The findings with respect to childbearing and menstrual history differ from those of a recent cohort study, and indicate the need for larger investigations to assess the role of these and other risk factors in the occurrence of sarcomas of the uterus. Cancer 64:2487–2492, 1989. References 1 Harlow BL, Weiss NS, Lofton S. The epidemiology of sarcoma of the uterus. J Natl Cancer Inst 1986; 76: 399–402. 2 JL Young, CL Percy, AJ Asire, eds. Cancer Incidence and Mortality in the United States, SEER, 1973–1981. Washington, DC: US Department of Health and Human Services, 1984; NIH publication no. 85–1837. 3 Schwartz Z, Dgani R, Lancet M, Kessler I. Uterine sarcomas in Israel: A study of 104 cases. Gynecol Oncol 1985; 20: 354–363. 4 Steinhorn SC, Myers MH, Hankey BF, Pelham VF. Factors associated with survival differences between black women and white women with cancer of the uterine corpus. Am J Epidemiol 1986; 124: 85–93. 5 Page HS, Asire AJ. Cancer Rates and Risks. Washington, DC: US DHHS, 1985; NIH publication no. 85–691. 6 Norris HJ, Taylor HB. Post-irradiation sarcomas of the uterus. Obstet Gynecol 1965; 26: 689–694. 7 Czesnin K, Wronkowski Z. Second malignancies of the irradiated area in patients treated for uterine cervix cancer. Gynecol Oncol 1978; 6: 309–315. 8 Wagoner JK. Leukemia and other malignancies following radiation therapy for gynecologic disorders. In: JD Boice, JF Fraumeni, eds. Radiation Carcinogenesis: Epidemiology and Biological Significance. New York: Raven, 1984; 153–159. 9 WHO Collaborative Study of Neoplasia and Steroid Contraceptives. Invasive cervical cancer and combined oral contraceptives. Br Med J 1985; 290: 961–965. 10 HE Poulson, CW Taylor, LH Sobin, eds. Histological typing of female genital tract tumours. In: International Classification of Tumours, vol. 13. Geneva: World Health Organization, 1975. 11 Breslow NE, Day NE. Statistical methods in cancer research: The analysis of case-control studies. Lyon: International Agency for Research on Cancer, 1981; 248–259. 12 Gart JJ. The comparison of proportions: A review of significance tests, confidence intervals, and adjustments for stratification. Rev Int Stat Inst 1971; 39: 148–169. 13 Thomas DG. Exact and asymptotic methods for the combination of 2 × 2 tables. Comp Biomed Res 1973; 8: 423–446. 14 Kvale G, Heuch I, Ursin G. Reproductive factors and risk of cancer of the uterine corpus: A prospective study. Cancer Res 1988; 48: 6217–6221. 15 Weiss NS. Epidemiology of carcinoma of the endometrium. Rev Cancer Epidemiol 1983; 2: 46–60. 16 Greene MH, Clark JW, Blayney DW. The epidemiology of ovarian cancer. Semin Oncol 1984; 11: 209–226. 17 Kelsey JL, Berkowitz GS. Breast cancer epidemiology. Cancer Res 1988; 48: 5615–5623. 18 Thomas DB. Do hormones cause breast cancer?. Cancer 1984; 53: 595–604. 19 Ross RK, Pike MC, Vessey MP, Bull D, Yeates D, Casagrande JT. Risk factors for uterine fibroids: Reduced risk associated with oral contraceptive use. Br Med J 1986; 293: 359–362. 20 Parazzini F, La Vecchia C, Negri E, Cecchetti G, Fedele L. Epidemiologic characteristics of women with uterine fibroids: A case-control study. Obstet Gynecol 1988; 72: 852–857. 21 The WHO Collaborative Study of Neoplasia and Steroid Contraceptives. Endometrial cancer and combined oral contraceptives. Int J Epidemiol 1988; 17: 263–269. 22 Weiss NS, Sayvetz T. Incidence of endometrial cancer in relation to use of oral contraceptives. N Engl J Med 1980; 302: 551–554. 23 The Centers for Disease Control. Oral contraceptive use and the risk of endometrial cancer. JAMA 1983; 249: 1600–1604. 24 Henderson BE, Casagrande JT, Pike MC, Mack T, Rosario I, Duke A. The epidemiology of endometrial cancer in young women. Br J Cancer 1983; 47: 749–756. Citing Literature Volume64, Issue1215 December 1989Pages 2487-2492 ReferencesRelatedInformation