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Reductive Amination with Zinc Borohydride. Efficient, Safe Route to Fluorinated Benzylamines

1997; Taylor & Francis; Volume: 27; Issue: 24 Linguagem: Inglês

10.1080/00397919708005050

1532-2432

Sukanta Bhattacharyya, Arindam Chatterjee, J. Williamson,

Chemical Synthesis and Reactions

Abstract Abstract: Fluorinated benzylamines are synthesized in high yields by reductive alkylation of secondary amines with appropriate fluoroaldehydes using a combination of zinc chloride and zinc borohydride. The present method offers an alternative to toxic sodium cyanoborohydride and is adaptable to multigram-scale preparations.