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Cadmium removal out of human plasma using ion-imprinted beads in a magnetic column

2008; Elsevier BV; Volume: 29; Issue: 1 Linguagem: Inglês

10.1016/j.msec.2008.06.002

1873-0191

Nilgün Candan, Nalan Tüzmen, Müge Andaç, Cenk A. Andac, Rıdvan Say, Adi̇l Deni̇zli̇,

Heavy Metal Exposure and Toxicity

The aim of this study is to utilize ion-imprinted magnetic beads in the selective removal of Cd2+ ions out of human plasma overdosed with Cd2+ ions. The Cd2+ imprinted magnetic poly(HEMA-MAC) (mPHEMAC-Cd2+) beads were produced by suspension polymerization in the presence of magnetite Fe3O4 in a nano-powder form. The template Cd2+ ions could be reversibly detached from the matrix to form mPHEMAC-Cd2+ beads using 0.1 M thiourea solution. The specific surface area of the mPHEMAC-Cd2+ beads was found to be 24.7 m2/g. The MAC and Fe3O4 contents of the mPHEMAC-Cd2+ beads were found to be 41.8 µmol/g polymer and 8.2% on the average. The Cd2+ adsorption capacity of mPHEMAC-Cd2+ columns decreased drastically from 48.8 µmol/g to 20.0 µmol/g as the flow rate is increased from 0.50 ml/min to 3.0 ml/min. The maximum adsorption capacity of the mPHEMAC-Cd2+ beads was determined to be 48.8 µmol Cd2+/g on the average. The relative selectivity coefficients of the mPHEMAC beads for Cd2+/Pb2+ and Cd2+/Zn2+ were 22.6 and 160.7 times greater than those of the non-imprinted magnetic PHEMAC (mPHEMAC) beads, respectively. The mPHEMAC-Cd2+ beads are reusable for many times with no significant decrease in their adsorption capacities.