Frontal lobe dementia is not a variant of prion disease
1993; Elsevier BV; Volume: 164; Issue: 1-2 Linguagem: Inglês
10.1016/0304-3940(93)90842-9
ISSN1872-7972
AutoresJoanne Clinton, David M. A. Mann, Gareth W. Roberts,
Tópico(s)Alzheimer's disease research and treatments
ResumoFrontal lobe dementia (FLD) is a syndromal diagnosis with a variable pathology. It has been argued that FLD is a dementing disorder which should be nosologically and etiologically distinguished from other types of dementia. However, similarities with prion disease and Alzheimer's disease have led to the suggestion that FLD is a variant of one or other of these dementias. We have tested this line of argument by examining the frontal cortex and cerebellum of 14 FLD cases and probing the molecular pathology using well characterised antibodies to prion protein and β-amyloid protein. No prion protein deposits or significant levels of β-amyloid protein were detected. FLD is a dementing disorder whose molecular pathology, whilst as yet uncharacterised, can be distinguished from those of other dementing disorders.
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