5-HT modifiers as a potential treatment of asthma
2000; Elsevier BV; Volume: 21; Issue: 1 Linguagem: Inglês
10.1016/s0165-6147(99)01408-x
ISSN1873-3735
AutoresMario Cazzola, Maria Gabriella Matera,
Tópico(s)Nicotinic Acetylcholine Receptors Study
ResumoIncreased levels of free 5-HT have been shown to be present in the plasma of symptomatic asthmatic patients compared with levels in asymptomatic patients. In addition, free 5-HT has been shown to correlate positively with clinical status and negatively with pulmonary function. These findings suggest that 5-HT might play a role in the pathophysiology of acute asthma. Accordingly, modifiers of the 5-HT transmitter system such as compounds that affect the 5-HT transporter, prejunctional 5-HT receptors or postsynaptic 5-HT receptors might represent a novel treatment of asthma.
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