Sulfoxide reductase activity of liver aldehyde oxidase
1983; Elsevier BV; Volume: 747; Issue: 1-2 Linguagem: Inglês
10.1016/0167-4838(83)90125-5
ISSN1878-1454
AutoresKiyoshi Tatsumi, Shigeyuki Kitamura, Hiroshi Yamada,
Tópico(s)Sulfur Compounds in Biology
ResumoThe present study provides evidence that guinea pig and rabbit liver aldehyde oxidase (EC 1.2.3.1) in the presence of its electron donors such as aldehydes or N-heterocyclic compounds functions as a sulfoxide reductase towards sulindac and other sulfoxide compounds. In addition, the study shows that a combination of liver aldehyde oxidase and milk xanthine oxidase also exhibits sulfoxide reductase activity in the presence of xanthine, an electron donor of xanthine oxidase. Based on these facts, we propose a new electron-transfer system consisting of these two flavoenzymes.
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