EFFECTS OF HYPOPHYSECTOMY AND HORMONES ON SULFHYDRYL CONCENTRATIONS IN RAT KIDNEY CELLS1
1957; Oxford University Press; Volume: 61; Issue: 2 Linguagem: Inglês
10.1210/endo-61-1-143
ISSN1945-7170
AutoresEdward J. Cafruny, E. Carhart, A. Farah,
Tópico(s)Birth, Development, and Health
ResumoANY change in water and electrolyte balance produced by a direct effect on renal tubular cells is related to alterations in tubular reabsorptive or secretory mechanisms. It has been demonstrated that mercurial diuresis occurs concomitantly with, and possibly as a result of, a depression in concentration of sulfhydryl groups in cells of terminal portions of the proximal tubules, loops of Henle, and collecting ducts (7, 8). Hormones which influence the state of renal tubular function might do so by affecting the concentration of sulfhydryl groups within renal cells and the studies included in this report were designed to test this hypothesis. A preliminary report has been published (6). Hypophysectomized albino, Sprague-Dawley rats (purchased from Hormone Assay Laboratories, Chicago, Ill.) weighing 80–100 gm. were used along with controls of the same age weighing 166–204 gm. The animals were kept in a room maintained at approximately 27° C and were fed a canned meat diet ad libitum.
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