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Sanguinarine-induced G1-phase arrest of the cell cycle results from increased p27KIP1 expression mediated via activation of the Ras/ERK signaling pathway in vascular smooth muscle cells

2008; Elsevier BV; Volume: 471; Issue: 2 Linguagem: Inglês

10.1016/j.abb.2008.01.008

1096-0384

Beob-Yi Lee, Se-Jung Lee, Sung Soo Park, Si‐Kwan Kim, Sung‐Ryong Kim, Jae Hyun Jung, Wun‐Jae Kim, Sung‐Kwon Moon,

Ubiquitin and proteasome pathways

The present study identified a novel mechanism for the effects of sanguinarine in vascular smooth muscle cells (VSMC). Sanguinarine treatment of VSMC resulted in significant growth inhibition as a result of G1-phase cell-cycle arrest mediated by induction of p27KIP1 expression, and resulted in a down-regulation of the expression of cyclins and CDKs in VSMC. Moreover, sanguinarine-induced inhibition of cell growth appeared to be linked to activation of Ras/ERK through p27KIP1-mediated G1-phase cell-cycle arrest. Overall, the unexpected effects of sanguinarine treatment in VSMC provide a theoretical basis for clinical use of therapeutic agents in the treatment of atherosclerosis.