Revisão Acesso aberto

Antibodies to DNA. A perspective

1986; Wiley; Volume: 29; Issue: 12 Linguagem: Inglês

10.1002/art.1780291201

ISSN

1529-0131

Autores

Woodruff Emlen, David S. Pisetsky, Ronald P. Taylor,

Tópico(s)

Chronic Lymphocytic Leukemia Research

Resumo

Arthritis & RheumatismVolume 29, Issue 12 p. 1417-1426 Current CommentFree to Read Antibodies to DNA. A perspective Woodruff Emlen MD, Corresponding Author Woodruff Emlen MD Associate Professor of Medicine Department of Medicine, University of Washington, Seattle the Department of Medicine, Duke University, Durham, North Carolina, and the Department of Biochemistry, University of Virginia, CharlottesvillePacific Medical Center, 1200 12th Avenue South, Seattle, WA 98144Search for more papers by this authorDavid S. Pisetsky Md, Phd, David S. Pisetsky Md, Phd Associate Professor of Medicine Department of Medicine, University of Washington, Seattle the Department of Medicine, Duke University, Durham, North Carolina, and the Department of Biochemistry, University of Virginia, CharlottesvilleSearch for more papers by this authorRonald P. Taylor PhD, Ronald P. Taylor PhD Professor of Biochemistry Department of Medicine, University of Washington, Seattle the Department of Medicine, Duke University, Durham, North Carolina, and the Department of Biochemistry, University of Virginia, CharlottesvilleSearch for more papers by this author Woodruff Emlen MD, Corresponding Author Woodruff Emlen MD Associate Professor of Medicine Department of Medicine, University of Washington, Seattle the Department of Medicine, Duke University, Durham, North Carolina, and the Department of Biochemistry, University of Virginia, CharlottesvillePacific Medical Center, 1200 12th Avenue South, Seattle, WA 98144Search for more papers by this authorDavid S. Pisetsky Md, Phd, David S. Pisetsky Md, Phd Associate Professor of Medicine Department of Medicine, University of Washington, Seattle the Department of Medicine, Duke University, Durham, North Carolina, and the Department of Biochemistry, University of Virginia, CharlottesvilleSearch for more papers by this authorRonald P. Taylor PhD, Ronald P. Taylor PhD Professor of Biochemistry Department of Medicine, University of Washington, Seattle the Department of Medicine, Duke University, Durham, North Carolina, and the Department of Biochemistry, University of Virginia, CharlottesvilleSearch for more papers by this author First published: December 1986 https://doi.org/10.1002/art.1780291201Citations: 77AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Tan EM, Schur PH, Carr RI, Kunkel HG: Deoxyribonucleic acid (DNA) and antibodies to DNA in the serum of patients with systemic lupus erythematosus. J Clin Invest 45: 1732– 1740, 1966 2 Koffler D, Schur PH, Kunkel HG: Immunological studies concerning the nephritis of systemic lupus erythematosus. J Exp Med 126: 607– 624, 1967 3 Koffler D: Immunopathogenesis of systemic lupus erythematosus. Annu Rev Med 25: 149– 164, 1974 4 Koffler D, Agnello V, Thoburn R, Kunkel HG: Systemic lupus erythematosus: prototype of immune complex nephritis in man. J Exp Med (suppl) 134: 169s– 179s, 1971 5 Izui S, Lambert PH, Miescher PA: Failure to detect circulating DNA-anti-DNA complexes by four radioimmunological methods in patients with systemic lupus erythematosus. Clin Exp Immunol 30: 384– 392, 1977 6 Rothfield NF, Stollar BD: The relation of immunoglobulin class, pattern of antinuclear antibody, and complement-fixing antibodies to DNA in sera from patients with systemic lupus erythematosus. J Clin Invest 46: 1785– 1794, 1967 7 Pincus T, Schur PH, Rose JA, Decker JL, Talal N: Measurement of serum DNA-binding activity in systemic lupus erythematosus. N Engl J Med 281: 701– 705, 1969 8 Miniter MF, Stollar BD, Agnello V: Reassessment of the clinical significance of native DNA antibodies in systemic lupus erythematosus. Arthritis Rheum 22: 959– 968, 1979 9 Miller TE, Lahita RG, Zarro VJ, Mac William J, Koffler D: Clinical significance of anti-double-stranded DNA antibodies detected by a solid phase enzyme immunoassay. Arthritis Rheum 24: 602– 610, 1981 10 Smeenk R, Lelij G, Aarden L: Avidity of antibodies to dsDNA: comparison of IFT on Crithidia luciliae, Farr assay, and PEG assay. J Immunol 128: 73– 78, 1982 11 Koffler D, Agnello V, Kunkel HG: Polynucleotide immune complexes in serum and glomeruli of patients with systemic lupus erythematosus. Am J Pathol 74: 109– 122, 1974 12 Krishnan C, Kaplan MH: Immunopathologic studies of systemic lupus erythematosus. II. Antinuclear reaction of gammaglobulin eluted from homogenates and isolated glomeruli of kidneys from patients with lupus nephritis. J Clin Invest 47: 569– 579, 1967 13 Borel Y, Lewis RM, Andre-Schwartz J, Stollar BD, Diener FJ: Treatment of lupus nephritis in adult (NZB + NZW) Fl mice by cortisone-facilitated tolerance to nucleic acid antigens. J Clin Invest 61: 276– 286, 1978 14 Hahn BH, Ebling FM: Suppression of NZB/NZW murine nephritis by administration of a syngeneic monoclonal antibody to DNA: possible role of anti-idiotypic antibodies. J Clin Invest 71: 1728– 1736, 1983 15 Aarden LA: Measurement of anti-DNA antibodies. Ann Rheum Dis (suppl) 36: 91– 95, 1977 16 Aarden LA, Degroot ER, Lakmaker F: Immunology of DNA. V. Analysis of DNA/anti-DNA complexes. J Immunol Methods 13: 241– 252, 1976 17 Riley RL, Addis DJ, Taylor RP: Stability of DNA/anti-DNA complexes. II. Salt lability and avidity. J Immunol 124: 1– 7, 1980 18 Emlen W, Ansari R, Burdick G: DNA-anti-DNA immune complexes: antibody protection of a discrete DNA fragment from DNAse digestion in vitro. J Clin Invest 74: 185– 190, 1984 19 Burdick G, Emlen W: Effect of antibody excess on the size, stoichiometry, and DNAse resistance of DNA anti-DNA immune complexes. J Immunol 135: 2593– 2597, 1985 20 Pedersen SE, Taylor RP, Morley KW, Wright EL: Stability of DNA/anti-DNA complexes. IV. Complement fixation. J Immunol Methods 38: 269– 280, 1980 21 Taylor RP, Horgan C: Quantitative determination of anti-dsDNA antibodies and antibody/dsDNA stoichiometries in prepared, soluble complement-fixing antibody/dsDNA immune complexes. Mol Immunol 21: 853– 862, 1984 22 Lennek R, Baldwin AS, Waller SJ, Morley KW, Taylor RP: Studies of the physical biochemistry and complement-fixing properties of DNA/anti-DNA immune complexes. J Immunol 127: 602– 608, 1980 23 Papalian M, Lafer E, Wong R, Stollar BD: Reaction of systemic lupus erythematosus antinative DNA with native DNA fragments from 20 to 1200 base pairs. J Clin Invest 65: 469– 477, 1980 24 Winfield JB, Koffler D, Kunkel HG: Specific concentration of polynucleotide immune complexes in the cryoprecipitates of patients with systemic lupus erythematosus. J Clin Invest 56: 563– 570, 1975 25 Halpern R, Schiffenbauer J, Solomon G, Diamond B: Detection of masked anti-DNA antibodies in lupus sera by a monoclonal anti-idiotype. J Immunol 133: 1852– 1856, 1984 26 Harbeck RJ, Bardana EJ, Kohler PF, Carr RI: DNA-anti-DNA complexes: their detection in systemic lupus erythematosus sera. J Clin Invest 52: 789– 795, 1973 27 Horgan C, Burge J, Crawford L, Taylor RP: The kinetics of [3H]-dsDNA/anti-DNA immune complex formation, binding by red blood cells, and release into serum: effect of DNA molecular weight and conditions of antibody excess. J Immunol 133: 2079– 2084, 1984 28 Sano H, Morimoto C: Isolation of DNA from DNA/anti-DNA antibody immune complexes in systemic lupus erythematosus. J Immunol 126: 538– 539, 1981 29 Steinman CR: Circulating DNA in systemic lupus erythematosus. Am J Med 67: 429– 435, 1979 30 McCoubrey-Hoyer A, Okarma TB, Holman HR: Partial purification and characterization of plasma DNA and its relation to disease activity in systemic lupus erythematosus. Am J Med 77: 23– 34, 1984 31 Raptis L, Menard HA: Quantitation and characterization of plasma DNA in normals and patients with SLE. J Clin Invest 66: 1391– 1399, 1980 32 Ali R, Dersimonian H, Stollar BD: Binding of monoclonal anti-native DNA autoantibodies to DNA of varying size and conformation. Mol Immunol 22: 1415– 1422, 1985 33 Emlen W, Mannik M: Clearance of circulating DNA-anti-DNA immune complexes in mice. J Exp Med 155: 1210– 1215, 1982 34 Emlen W, Burdick G: Clearance of model DNA anti-DNA immune complexes in mice (abstract). Arthritis Rheum (suppl) 28: S40, 1985 35 Cornacoff JB, Hebert LA, Smead WL, van Aman ME, Birmingham DJ, Waxman FJ: Primate erythrocyte-immune complex-clearing mechanism. J Clin Invest 71: 236– 247, 1983 36 Taylor RP, Kujala G, Wilson K, Wright E, Harbin A: In vivo and in vitro studies of the binding of antibody/dsDNA immune complexes to rabbit and guinea pig platelets. J Immunol 134: 2550– 2558, 1985 37 Taylor RP, Kujala G, Edberg JC, Foreman P, Davis JS, Wright E: The kinetics of clearance of human antibody/dsDNA immune complexes from rabbit circulation: effects of dsDNA size, rheumatoid factor, and reduction and alkylation of the antibodies. J Immunol 136: 3785– 3792, 1986 38 Taylor RP, Horgan C, Hooper M, Burge J: Dynamics of interaction between complement-fixing antibody/dsDNA immune complexes and erythrocytes: in vitro studies and potential general applications to clinical immune complex testing. J Clin Invest 75: 102– 111, 1985 39 Miyakawa Y, Yamada A, Kosaka K, Tsuda F, Kosugi E, Mayumi M: Defective immune-adherence (C3b) receptor on erythrocytes from patients with systemic lupus erythematosus. Lancet ii: 493– 497, 1981 40 Frank MM, Hamburger MI, Lawley TJ, Kimberly RP, Plotz PH: Defective reticuloendothelial system Fc-receptor function in systemic lupus erythematosus. N Engl J Med 300: 518– 523, 1979 41 Izui S, Lambert PH, Miescher PH: In vitro demonstration of a particular affinity of glomerular basement membrane and collagen for DNA: a possible basis for a local formation of DNA-anti-DNA complexes in systemic lupus erythematosus. J Exp Med 144: 428– 443, 1976 42 Cukier R, Tron F: Monoclonal anti-DNA antibodies: an approach to studying SLE nephritis. Clin Exp Immunol 62: 143– 149, 1985 43 Ebling F, Hahn BH: Restricted subpopulations of DNA antibodies in kidneys of mice with systemic lupus: comparison of antibodies in serum and renal eluates. Arthritis Rheum 23: 392– 403, 1980 44 Faarber P, Capel PJA, Rijke GPM, Vierwinden G, van de Putte LBA, Koene RAP: Cross-reactivity of anti-DNA antibodies with proteoglycans. Clin Exp Immunol 55: 502– 508, 1984 45 Hahn BH: Characteristics of pathogenic subpopulations of antibodies to DNA. Arthritis Rheum 25: 747– 752, 1982 46 Gauthier VJ, Striker GE, Mannik M: Glomerular localization of performed immune complexes prepared with anionic antibodies or with cationic antigens. Lab Invest 50: 636– 644, 1984 47 Dang H, Harbeck RJ: The in vivo and in vitro glomerular deposition of isolated anti-double-stranded-DNA antibodies in NZB/W mice. Clin Immunol Immunopathol 30: 265– 278, 1984 48 Yoshida H, Yoshida M, Izui S, Lambert PH: Distinct clonotypes of anti-DNA antibodies in mice with lupus nephritis. J Clin Invest 76: 685– 694, 1985 49 Eilat D: Cross-reactions of anti-DNA antibodies and the central dogma of lupus nephritis. Immunol Today 6: 123– 127, 1985 50 Eilat D: Monoclonal autoantibodies: an approach to studying autoimmune disease. Mol Immunol 19: 943– 955, 1982 51 Schwartz RS, Stollar BD: Origins of anti-DNA antibodies. J Clin Invest 75: 321– 327, 1985 52 Pisetsky DS: Hybridoma SLE autoantibodies: insights for the pathogenesis of autoimmune disease. Clin Immunol Rev 3: 169– 234, 1984 53 Schroer KR, Kim KJ, Prescott B, Baker PJ: Generation of anti-type III pneumococcal polysaccharide hybridomas from mice with an X-linked B-lymphocyte defect. J Exp Med 150: 698– 702, 1979 54 Shoenfeld Y, Hsu-Lin SC, Gabriels JE, Silberstein LE, Furie BC, Furie B, Stollar BD, Schwartz RS: Production of autoantibodies by human-human hybridomas. J Clin Invest 70: 205– 208, 1982 55 Rauch J, Massicotte H, Tannenbaum H: Hybridoma anti-DNA autoantibodies from patients with rheumatoid arthritis and systemic lupus erythematosus demonstrate similar nucleic acid binding characteristics. J Immunol 134: 180– 186, 1985 56 Hahn BH, Ebling F, Freeman S, Clevinger B, Davie J: Production of monoclonal murine autoantibodies to DNA by somatic cell hybrids. Arthritis Rheum 23: 942– 945, 1980 57 Andrzejewski C, Rauch J, Lafer E, Stollar BD, Schwartz RS: Antigen-binding diversity and idiotypic cross-reactions among hybridoma autoantibodies to DNA. J Immunol 126: 226– 231, 1981 58 Marion TN, Lawton AR, Kearney JF, Briles DE: Anti-DNA autoantibodies in (NZB X NZW) Fl mice are clonally heterogeneous, but the majority share a common idiotype. J Immunol 128: 668– 674, 1982 59 Shoenfeld Y, Rauch J, Massicotte H, Datta SK, Andre-Schwartz J, Stollar BD, Schwartz RS: Polyspecificity of monoclonal lupus autoantibodies produced by human-human hybridomas. N Engl J Med 308: 414– 420, 1983 60 Moller A, Gabriels JE, Lafer EM, Nordheim A, Rich A, Stollar BD: Monoclonal antibodies recognize different parts of Z-DNA. J Biol Chem 257: 12081– 12085, 1982 61 Lafer EM, Rauch J, Andrzejewski C, Mudd D, Furie BC, Furie B, Schwartz RS, Stollar BD: Polyspecific monoclonal lupus autoantibodies reactive with both polynucleotides and phospholipids. J Exp Med 153: 897– 909, 1981 62 Rubin RL, Balderas RS, Tan EM, Dixon FJ, Theofilopoulos AN: Multiple autoantigen binding capabilities of mouse monoclonal antibodies selected for rheumatoid factor activity. J Exp Med 159: 1429– 1440, 1984 63 Andre-Schwartz J, Datta SK, Shoenfeld Y, Isenberg DA, Stollar BD, Schwartz RS: Binding of cytoskeletal proteins by monoclonal anti-DNA lupus autoantibodies. Clin Immunol Immunopathol 31: 261– 271, 1984 64 Jacob L, Tron F, Bach JF, Louvard D: A monoclonal anti-DNA antibody also binds to cell-surface protein(s). Proc Natl Acad Sci USA 81: 3843– 3845, 1984 65 Carroll P, Stafford D, Schwartz RS, Stollar BD: Murine monoclonal anti-DNA autoantibodies bind to endogenous bacteria. J Immunol 135: 1086– 1090, 1985 66 Pisetsky DS, Hoch SO, Klatt CL, O'Donnell MA, Keene JD: Specificity and idiotypic analysis of a monoclonal anti-Sm antibody with anti-DNA activity. J Immunol 135: 4080– 4085, 1985 67 Rauch J, Tannenbaum H, Stollar BD, Schwartz RS: Monoclonal anti-cardiolipin antibodies bind to DNA. Eur J Immunol 14: 529– 534, 1984 68 Diamond B, Scharff MD: Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity. Proc Natl Acad Sci USA 81: 5841– 5844, 1984 69 Pisetsky DS, Caster SA: The B cell repertoire for autoantibodies: frequency of precursor cells for anti-DNA antibodies. Cell Immunol 72: 294– 305, 1982 70 Rauch J, Murphy E, Roth JB, Stollar BD, Schwartz RS: A high frequency idiotypic marker of anti-DNA autoantibodies in MRL-lpr/lpr mice. J Immunol 129: 236– 241, 1982 71 Datta SK, Stollar BD, Schwartz RS: Normal mice express idiotypes related to autoantibody idiotypes of lupus mice. Proc Natl Acad Sci USA 80: 2723– 2727, 1983 72 Tron F, Jacob L, Bach JF: Murine monoclonal anti-DNA antibodies with an absolute specificity for DNA have a large amount of idiotypic diversity. Proc Natl Acad Sci USA 80: 6024– 6027, 1983 73 Hahn BH, Ebling FM: A public idiotypic determinant is present on spontaneous cationic IgG antibodies to DNA from mice of unrelated lupus-prone strains. J Immunol 133: 3015– 3019, 1984 74 Mayus JL, Pisetsky DS: Expression of a highly conserved anti-DNA idiotype in normal and autoimmune mice. Clin Immunol Immunopathol 34: 366– 378, 1985 75 Cairns E, Block J, Bell DA: Anti-DNA autoantibody producing hybridomas of normal human lymphoid cell origin. J Clin Invest 74: 880– 886, 1984 76 Datta SK, Naparstek Y, Schwartz RS: In vitro production of an anti-DNA idiotype by lymphocytes of normal subjects and patients with systemic lupus erythematosus. Clin Immunol Immunopathol 38: 302– 317, 1986 77 Hannestad K: Gamma-M rheumatoid factors reacting with nitrophenyl groups and denatured deoxyribonucleic acid. Ann NY Acad Sci 168: 63– 75, 1969 78 Harris EN, Gharavi AE, Loizou S, Derue G, Chan JK, Patel BM, Mackworth-Young CG, Bunn CC, Hughes GRV: Crossreactivity of antiphospholipids. J Clin Lab Immunol 16: 1– 6, 1985 79 Harris EN, Gharavi AE, Tincani A, Chan JKH, Englert H, Mantelli P, Allegro F, Ballestrieri G, Hughes GRV: Affinity purified anti-cardiolipin and anti-DNA antibodies. J Clin Lab Immunol 17: 155– 162, 1985 80 Edberg JC, Taylor RP: Quantitative aspects of lupus anti-DNA autoantibody specificity. J Immunol 136: 4581– 4587, 1986 81 Ballard DW, Voss EW Jr: Base specificity and idiotypy of anti-DNA autoantibodies reactive with synthetic nucleic acids. J Immunol 135: 3372– 3380, 1985 82 Izui S, Lambert PH, Miescher PA: Determination of anti-DNA antibodies by a modified 125I-labelled DNA-binding test: elimination of nonspecific binding of DNA to non-immunoglobulin basic proteins by using an anionic detergent. Clin Exp Immunol 26: 425– 430, 1976 Citing Literature Volume29, Issue12December 1986Pages 1417-1426 ReferencesRelatedInformation

Referência(s)
Altmetric
PlumX