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Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3-hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist and its water-soluble prodrug phosphate ester

1992; American Chemical Society; Volume: 35; Issue: 19 Linguagem: Inglês

10.1021/jm00097a005

1520-4804

N. N. Girotra, Tesfaye Biftu, Mitree M. Ponpipom, John J. Acton, Alfred W. Alberts, Tobias Bach, Richard G. Ball, Robert L. Bugianesi, John C. Chabala,

Synthesis and Reactivity of Sulfur-Containing Compounds

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDevelopment, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3-hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist and its water-soluble prodrug phosphate esterN. N. Girotra, T. Biftu, M. M. Ponpipom, J. J. Acton, A. W. Alberts, T. N. Bach, R. G. Ball, R. L. Bugianesi, J. C. Chabala, and Cite this: J. Med. Chem. 1992, 35, 19, 3474–3482Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published inissue 1 September 1992https://pubs.acs.org/doi/10.1021/jm00097a005https://doi.org/10.1021/jm00097a005research-articleACS PublicationsRequest reuse permissionsArticle Views362Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts