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A controlled trial of naftidrofuryl (Praxilene) in the treatment of intermittent claudication

1980; Oxford University Press; Volume: 67; Issue: 5 Linguagem: Inglês

10.1002/bjs.1800670515

1365-2168

C A C Clyne, R B Galland, Michael Fox, R Gustave, Georges Jantet, C W Jamieson,

Coagulation, Bradykinin, Polyphosphates, and Angioedema

Abstract We present the results of a double-blind trial of naftidrofuryl (Praxilene) in the treatment of intermittent claudication. One hundred and twenty-eight patients were subjected to a standard walking test 3 and 6 months after treatment. There was no significant objective improvement attributable to the drug. Although both groups significantly increased their walking time to the onset of pain, those patients over 60 years old taking naftidrofuryl showed a significant improvement over their pretreatment walking times to onset of pain, whereas their controls did not.