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An ionic liquid influenced l-proline catalysed asymmetric Michael addition of ketones to nitrostyrene

2005; Elsevier BV; Volume: 235; Issue: 1-2 Linguagem: Inglês

10.1016/j.molcata.2005.03.024

1873-314X

Meghana S. Rasalkar, Mahesh K. Potdar, Swapnil S. Mohile, Manikrao M. Salunkhe,

Asymmetric Synthesis and Catalysis

l-Proline in ionic liquid was employed for Michael addition of ketones to nitrostyrene. Optically active γ-nitroketones were obtained in good yields up to 80%. The reaction offers high syn selectivity (90%). The most striking feature is that the ionic liquid has been found to enhance the enantioselectivity, wherein enantiomeric excess approaches 75%. The system of ionic liquid and catalyst has proved to be an efficient recyclable medium.