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Homologies between human and dolphin chromosomes detected by heterologous chromosome painting

1998; Karger Publishers; Volume: 81; Issue: 1 Linguagem: Inglês

10.1159/000015002

1424-8581

P.E. Bielec, D.S. Gallagher, James E. Womack, David L. Busbee,

Congenital heart defects research

Human chromosome-specific probes for the entire karyotype were hybridized to metaphase spreads of the Atlantic bottlenose dolphin, <i>Tursiops truncatus, </i>to directly compare the evolutionary conservation of chromosomal segments between these two distantly related species. All human chromosomal paints, except the Y probe, hybridized to <i>Tursiops</i> counterparts, and every dolphin chromosome was painted except for the smallest submetacentric pair. In our analysis, 36 segments of conserved synteny common to the human and dolphin genomes were identified. The distribution of conserved chromosomal segments and the specific rearrangement patterns found between the two genomes are presented and discussed.