Acute neurotoxicity of the Lathyrus sativus neurotoxin, l-3-oxalylamino-2-aminopropionic acid, in the squirrel monkey
1979; Elsevier BV; Volume: 47; Issue: 1 Linguagem: Inglês
10.1016/0041-008x(79)90080-2
ISSN1096-0333
AutoresAlan J. Parker, Tara Mehta, Nabi S. Zarghami, Patrick K. Cusick, Betty E. Haskell,
Tópico(s)Toxin Mechanisms and Immunotoxins
ResumoThis paper provides the first evidence that the Lathyrus sativus neurotoxin, l-3-oxalylamino-2-aminopropionic Acid (OAP), is toxic when administered intraperitoneally to a primate with a mature bloodbrain barrier. Drowsiness, vomiting, muscle tremors, twitching, convulsions, and death occurred in young male squirrel monkeys (Saimiri sciureus) following injection of 4.26 and 11.4 μmol (0.750 and 2.00 mg) OAP/g body wt. Electroencephalographic changes characteristic of each stage of intoxication were observed. Unchanged OAP was recovered from brain of intoxicated animals. These observations support a possible role for OAP in the etiology of human neurolathyrism, a paralytic disease prevalent among adults in Central India who have consumed large quantities of L. sativus seeds for several months.
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