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Procalcitonin Versus C-Reactive Protein for Guiding Antibiotic Therapy in Sepsis

2013; Lippincott Williams & Wilkins; Volume: 41; Issue: 10 Linguagem: Inglês

10.1097/ccm.0b013e31828e969f

1530-0293

Carolina Oliveira, Fernando Antônio Botoni, Clara Rodrigues Alves de Oliveira, Camila B. Silva, Héléna Pereira, José Carlos Serufo, Vandack Nobre,

Hemodynamic Monitoring and Therapy

We sought to evaluate whether procalcitonin was superior to C-reactive protein in guiding antibiotic therapy in intensive care patients with sepsis.Randomized open clinical trial.Two university hospitals in Brazil.Patients with severe sepsis or septic shock.Patients were randomized in two groups: the procalcitonin group and the C-reactive protein group. Antibiotic therapy was discontinued following a protocol based on serum levels of these markers, according to the allocation group. The procalcitonin group was considered superior if the duration of antibiotic therapy was at least 25% shorter than in the C-reactive protein group. For both groups, at least seven full-days of antibiotic therapy were ensured in patients with Sequential Organ Failure Assessment greater than 10 and/or bacteremia at inclusion, and patients with evident resolution of the infectious process had antibiotics stopped after 7 days, despite biomarkers levels.Ninety-four patients were randomized: 49 patients to the procalcitonin group and 45 patients to the C-reactive protein group. The mean age was 59.8 (SD, 16.8) years. The median duration of antibiotic therapy for the first episode of infection was 7.0 (Q1-Q3, 6.0-8.5) days in the procalcitonin group and 6.0 (Q1-Q3, 5.0-7.0) days in the C-reactive protein group (p=0.13), with a hazard ratio of 1.206 (95% CI, 0.774-1.3; p=0.13). Overall, protocol overruling occurred in only 13 (13.8%) patients. Twenty-one patients died in each group (p=0.836).C-reactive protein was as useful as procalcitonin in reducing antibiotic use in a predominantly medical population of septic patients, causing no apparent harm.