Hippocampal serotonin levels influence the expression of S100β detected by immunocytochemistry
1993; Elsevier BV; Volume: 631; Issue: 1 Linguagem: Inglês
10.1016/0006-8993(93)91195-x
ISSN1872-6240
AutoresJohn H. Haring, Alan Hagan, James E. Olson, Bret Rodgers,
Tópico(s)Cell Adhesion Molecules Research
ResumoThe response of astrocytes to pharmacological alterations of the serotonin (5-HT) content of the dorsal area dentata was studied by immunocytochemistry for S100β. Stereological analysis revealed changes in the density of astrocytic elements in conditions of 5-HT depletion and elevated 5-HT levels. There was a direct relationship between the expression of S100β and the level of 5-HT in the hippocampal formation. Thus when 5-HT was reduced by PCPA treatment, S100β immunoreactivity was also reduced. The converse of these observations was obtained in cases where the 5-HT levels were increased by fluoxetine administration. These immunocytochemical data are consistant with previous reports of the response of astrocytes to 5-HT in vitro.
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