Portal de Periódicos da CAPES

Neuregulins as Potential Neuroprotective Agents

1997; Wiley; Volume: 825; Issue: 1 Linguagem: Francês

10.1111/j.1749-6632.1997.tb48446.x

1749-6632

Mark A. Marchionni, Judith B. Grinspan, Peter Canoll, Nagesh K. Mahanthappa, James L. Salzer, Steven S. Scherer,

Signaling Pathways in Disease

Annals of the New York Academy of SciencesVolume 825, Issue 1 p. 348-365 Neuregulins as Potential Neuroprotective Agents MARK A. MARCHIONNI, Corresponding Author MARK A. MARCHIONNI Cambridge NeuroScience, Inc. One Kendall Square Cambridge, Massachusetts 01239 Corresponding author. Tel: (617) 225-0600, ext. 140; fax: (617) 225-2741; email: [email protected]Search for more papers by this authorJUDITH B. GRINSPAN, JUDITH B. GRINSPAN Division of Neurological Research Children's Hospital of Philadelphia Philadelphia, Pennsylvania 19104Search for more papers by this authorPETER D. CANOLL, PETER D. CANOLL Department of Cell Biology New York University Medical School New York, New York 10016Search for more papers by this authorNAGESH K. MAHANTHAPPA, NAGESH K. MAHANTHAPPA Cambridge NeuroScience, Inc. One Kendall Square Cambridge, Massachusetts 01239Search for more papers by this authorJAMES L. SALZER, JAMES L. SALZER Department of Cell Biology New York University Medical School New York, New York 10016Search for more papers by this authorSTEVEN S. SCHERER, STEVEN S. SCHERER Department of Neurology University of Pennsylvania Medical Center Philadelphia, Pennsylvania 19104Search for more papers by this author MARK A. MARCHIONNI, Corresponding Author MARK A. MARCHIONNI Cambridge NeuroScience, Inc. One Kendall Square Cambridge, Massachusetts 01239 Corresponding author. Tel: (617) 225-0600, ext. 140; fax: (617) 225-2741; email: [email protected]Search for more papers by this authorJUDITH B. GRINSPAN, JUDITH B. GRINSPAN Division of Neurological Research Children's Hospital of Philadelphia Philadelphia, Pennsylvania 19104Search for more papers by this authorPETER D. CANOLL, PETER D. CANOLL Department of Cell Biology New York University Medical School New York, New York 10016Search for more papers by this authorNAGESH K. MAHANTHAPPA, NAGESH K. MAHANTHAPPA Cambridge NeuroScience, Inc. One Kendall Square Cambridge, Massachusetts 01239Search for more papers by this authorJAMES L. SALZER, JAMES L. SALZER Department of Cell Biology New York University Medical School New York, New York 10016Search for more papers by this authorSTEVEN S. SCHERER, STEVEN S. SCHERER Department of Neurology University of Pennsylvania Medical Center Philadelphia, Pennsylvania 19104Search for more papers by this author First published: 17 December 2006 https://doi.org/10.1111/j.1749-6632.1997.tb48446.xCitations: 12Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL REFERENCES 1 Lemke, G. 1996. Neuregulins in development. Mol. Cell. Neurosci. 7: 247– 262. 2 Marchionni, M. A., C. J. Kirk, I. J. Isaacs, C. J. Hoban, N. K. Mahanthappa, E. S. Anton, C. Chen. F. Wason, D. Lawson, F. P. T. Hamers, P. D. Canoll, R. Reynolds, B. Cannella, D. Meun, W. F. Holt, W. D. Matthew, L. E. Chen. W. H. Gispen, C. S. Raine, J. L. Salzer & D. I. Gwynne. 1996. Neuregulins as potential drugs for neurological disorders. In Function and Dysfunction in the Nervous System. B. Stillman, Ed. Cold Spring Harbor Symp. Quant. Biol. 61. In press. 3 Wen, D., E. Pfles. R. Cupples, S. V. Suggs, S. S. Bacus, Y. Luo, G. Trail, S. Hu, S. M. Silbiger, R. B. Levy et al. 1992. Neu differentiation factor; a transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit. Cell 69: 559– 572. 4 Holmes, W. E., M. X. Sliwkowski, R. W. Akita, W. J. Henzel. J. Lee, J. W. Park, D. Yansura, N. Abadi, H. Raab, G. D. Lewis et al. 1992. Identification of heregulin, a specific activator of p185erbB2. Science 256: 1205– 1210. 5 Marchionni, M. A., A. D. Goodearl, M. S. Chen, O. Bermingham-Mcdonogh, C. Kirk, M. Hendricks, F. Danehy, D. Misumi, J. Sudhalter, K. Kobayashi, D. Wroblewski, C. Lynch, M. Baldassare, I. Hiles, J. B. Davis, J. Hsuan, J. J. Totty, M. Otsu, R. N. Mcburney, M. D. Waterfield, P. Stroobant & D. Gwynne. 1993. Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system. Nature 362: 312– 318. 6 Falls, D. L., K. M. Rosen, G. Corfas, W. S. Lane & G. D. Fischbach. 1993. ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family. Cell 72: 801– 815. 7 Meyer, D. & C. Birchmeier. 1995. Multiple essential functions of neuregulin in development. Nature 378: 386– 390. 8 Lee, K. F., H. Simon, H. Chen, B. Bates, M. C. Hung & C. Hauser. 1995. Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 378: 394– 398. 9 Gassmann, M., F. Casagranda, D. Orioli, H. Simon, C. Lai, R. Klein & G. Lemke. 1995. Aberrant neural and cardiac development in mice lacking the erbB4 neuregulin receptor. Nature 378: 390– 394. 10 Chen, M. S., O. Bermingham-Mcdonogh, F. Danehy, Jr., C. Nolan, S. S. Scherer, J. Lucas, D. Gwynne & M. A. Marchionni. 1994. Expression of multiple neuregulin transcripts in postnatal rat brains. J. Comp. Neurol. 349: 389– 400. 11 Corfas, G., K. M. Rosen, H. Aratake, R. Krauss & G. D. Fischbach. 1995. Differential expression of ARIA isoforms in the rat brain. Neuron 14: 103– 115. 12 Pinkas-Kramarski R., R. Eilam, O. Spiegler, S. Lavi, N. Liu, D. Chang, D. Wen, M. Schwartz & Y. Yarden. 1994. Brain neurons and glial cells express Neu differentiation factor/heregulin: a survival factor for astrocytes. Proc. Natl. Acad. Sci. USA 91: 9387– 9391. 13 Jo, S. A., X. Zhu, M. A. Marchionni & S. J. Burden. 1995. Neuregulins are concentrated at nerve-muscle synapses and activate ACh receptor gene expression. Nature 373: 158– 161. 14 Sandrock, A. W., Jr., A. D. J. Goodearl, Q-W. Yin, D. Chang & G. D. Fischbach. 1995. ARIA is concentrated in nerve terminals at neuromuscular junctions and at other synapses. J. Neurosci. 15: 6124– 6136. 15 Bermingham-Mcdonogh, O., K. L. Mccabe & T. A. Reh. 1996. Effects of GGF/neuregulins on neuronal survival and neurite outgrowth correlate with erbB2/neu expression in developing rat retina. Development 122: 1427– 1438. 16 Vartanian, T., G. Corfas, Y. Li, G. Fischbach & K. Stefansson. 1994. A role for the acetylcholine receptor-inducing protein ARIA in oligodendrocyte development. Proc. Natl. Acad. Sci. USA 91: 11626– 11630. 17 Rutkowski, J. L., C. J. Kirk, M. A. Lerner & G. I. Tennekoon. 1995. Purification and expansion of human Schwann cells in vitro. Nature Med. 1: 80– 83. 18 Levi, A. D. O., R. P. Bunge, J. A. Lofgren, L. Meima, F. Hefti, K. Nikolics & M. X. Sliwkowski, 1995. The influence of heregulins on human Schwann cell proliferation. J. Neurosci. 14: 1329– 1340. 19 Morrissey, T. K., A. D. O. Levi, A. Nuijens, M. X. Sliwkowski & R. P. Bunge. 1995. Axon-induced mitogenesis of human Schwann cells involves heregulin and p185erbB2. Proc. Natl. Acad. Sci. USA 92: 1431– 1435. 20 Dong, Z., A. Brennan, N. Liu, Y. Yarden, G. Lefkowitz, R. Mirsky & K. R. Jessen. 1995. Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat Schwanu cell precursors. Neuron 15: 585– 596. 21 Trachtenberg, J. T. & W. J. Thompson. 1996. Schwann cell apoptosis at developing neuromuscular junctions is regulated by glial growth factor. Nature 379: 174– 177. 22 Cheng, L. & A. W. Mudge. 1996. Cultured Schwann cells constitutively express the myelin protein P0. Neuron 16: 309– 319. 23 Canoll, P. D., J. M. Musacchio, R. Hardy, R. Reynolds, M. A. Marchionni & J. L. Salzer. 1996. GGF/neuregulin is a neuronal signal that promotes the proliferation and survival and inhibits the differentiation of oligodendrocyte progenitors. Neuron 17: 229– 243. 24 Grinspan, J. B., M. A. Marchionni, M. Reeves, M. Coulaloglou & S. S. Scherer. 1996. Axonal interactions regulate Schwann cell apoptosis in developing peripheral nerve: neuregulin receptors and the role of neuregulins. J. Neurosci. 16: 6107– 6118. 25 Syroid, D. E., P. R. Maycox, P. G. Burrola, N. Liu, D. Wen. K-F. Lee, G. Lemke & T. J. Kilpatrick. 1996. Cell death in the Schwann cell lineage and its regulation by neuregulin. Proc. Natl. Acad. Sci. USA 93: 9229– 9234. 26 Henderson, C. E., H. S. Phillips, R. A. Pollock, A. M. Davies, C. Lemeulle, M. Armanini, L. C. Simpson, B. Moffet, R. A. Vandlen, V. E. Koliatsos & A. Rosenthal. 1994. GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle. Science 266: 1062– 1064. 27 Verdi, J. M., A. K. Groves, I. Farinas, K. Jones, M. A. Marchionni, L. F. Reichardt & D. J. Anderson. 1996. A reciprocal cell-cell interaction mediated by neurotrophin-3 and neuregulins controls the early survival and development of sympathetic neuro-blasts. Neuron 16: 515– 527. 28 Mahanthappa, N. K., E. S. Anton & W. D. Matthew. 1996. Glial growth factor 2, a soluble neuregulin, directly increases Schwann cell motility and indirectly promotes neurite outgrowth. J. Neuroscience 16: 4673– 4683. 29 Altman, J. 1966. Proliferation and migration of undifferentiated precursor cells in the rat during postnatal gliogenesis. Exp. Neurol. 16: 263– 278. 30 Goldman, J. E. 1992. Regulation of oligodendrocyte differentiation. TINS 15: 359– 362. 31 Barres, B. A. & M. C. Raff. 1994. Control of oligodendrocyte number in the developing rat optic nerve. Neuron 12: 935– 942. 32 Hardy, R. & R. Reynolds, 1993. Rat cerebral cortical neurons in primary culture release a mitogen specific for early (GD3+/O4−) oligodendroglial progenitors. J. Neurosci. Res 34: 589– 600. 33 Orr-Urtreger, A., L. Trakhtenbrot, R. Ben-Levy, D. Wen, G. Rechavi, P. Lonai & Y. Yarden. 1993. Neural expression and chromosomal mapping of Neu differentiation factor to 8p12-p21. Proc. Natl. Acad Sci. USA 90: 1867– 1871. 34 Louis, J. C., E. Magal, D. Mum, M. Manthorpe & S. Varon. 1992. CG-4, a new bipotential glial cell line from rat brain, is capable of differentiating in vitro into either mature oligodendrocytes or type-2 astrocytes. J. Neurosci. Res. 31: 193– 204. 35 Barres, B. A., I. K. Hart, H. S. R. Coles, J. F. Burne, J. T. Voyvodic, W. D. Richardson & M. C. Raff. 1992. Cell death and control of cell survival in the oligodendrocyte lineage. Cell 70: 31– 46. 36 Cannoll, P. & J. L. Salzer. Personal communication. 37 Raff, M. C., E. Abney, J. P. Brockes & A. Hornby-Smith. 1978. Schwann cell growth factors. Cell 15: 813– 822. 38 Stemple, D. L. & D. J. Anderson. 1991. A Schwann cell antigen recognized by monoclonal antibody 217c is the rat low-affinity nerve growth factor receptor. Neurosci. Lett. 124: 57– 60. 39 Gillespie, C. S., D. L. Sherman, G. E. Blair & P. J. Brophy. 1994. Periaxin, a novel protein of myelinating Schwann cells with a possible role in axonal ensheathmemt. Neuron 12: 497– 508. 40 Scherer, S. S., Y-T. Xu, P. Bannerman, D. L. Sherman & P. J. Brophy. 1995. Periaxin expression in myelinating Schwann cells: modulation by axon-glial interactions and polarized localization during development. Development 121: 4265– 4273. 41 Barbacid, M. 1994. The trk family of neurotrophin receptors. J. Neurobiol. 25: 386– 1403. 42 Funakoshi, H., J. Frisen, G. Barbany, T. Timmusk, O. Zachrisson, V. M. K. Verge & H. Persson. 1993. Differential expression of mRNA's for neurotrophins and their receptors after axotomy of the sciatic nerve. J. Cell Biol. 123: 455– 465. 43 Bunge, R. P. 1994. The role of the Schwann cell in trophic support and regeneration. J. Neurol. 241: 19– 21. 43b Scherer, S. S. & J. L. Salzer. 1996. Axon-Schwann cell interactions during peripheral nerve degeneration and regeneration. In Glial Cell Development. K. R. Jessen & W. D. Richardson, Eds. Bios Scientific Publishers. Oxford . 44 Li, L., R. W. Oppenheim & L. J. Houenou. 1994. Neurotrophic agents prevent motoneuron death following sciatic nerve section in the neonatal mouse. J. Neurobiol. 25: 759– 766. 45 Sham, N. M., M. A. Marchionni, I. Isaacs, P. Stroobant & D. J. Anderson. 1994. Glial growth factor restricts mammalian neural crest stem cells to a dial fate. Cell 77: 349– 360. 46 Lindsay, R. M. 19XX. Therapeutic potential of the neurotrophins and neurotrophin-CNTF combinations in peripheral neuropathies and motor neuron diseases. In Growth Factors as Drugs for Neurological and Sensory Disorders. G. R. Bock & J. A. Goode. Eds. CIBA Foundation Symp. Vol. 196: 39. Wiley. Chicester . 47 Ikeda, K., B. Klinkosz, T. Greene, J. M. Cedarbaum, V. Wong, R. M. Lindsay & H. Mitsumoto. 1995. Effects of brain-derived neurotrophic factor on motor dysfunction in wobbler motor neuron disease. Ann. Neurol. 37: 505– 511. 48 Apfel, S. C. & J. A. Kessler. 19XX. Neurotrophic factors in the treatment of peripheral neuropathy. In Growth Factors as Drugs for Neurological and Sensory Disorders. G. R. Bock & J. A. Goode, Eds. CIBA Foundation Symp. Vol. 196: 98. Wiley. Chicester . 49 Vaught, J. L., P. C. Contreras, M. A. Glicksman & N. T. Neff. 19XX. Potential utility of rhIGF-1 in neuromuscular and/or degenerative disease. In Growth Factors as Drugs for Neurological and Sensory Disorders. G. R. Bock & J. A. Goode, Eds. CIBA Foundation Symp. Vol. 196: 18. Wiley. Chicester . 50 Ho, W. H., M. P. Armanini, A. Nuijens, H. S. Phillips & P. L. Osheroff. 1995. Sensory and motor neuron-derived factor: a novel heregulin variant highly expressed in sensory and motor neurons. J. Biol. Chem. 270: 14523– 14532. 51 Peles, E., & Y. Yarden. 1993. Neu and its ligands: from an oncogene to neural factors. Bioessays 15: 815– 824. Citing Literature Volume825, Issue1Neuroprotective Agents: Third International ConferenceOctober 1997Pages 348-365 ReferencesRelatedInformation